Methylglyoxal synthase

Methylglyoxal synthase
methylglyoxal synthase
Identifiers
EC number 4.2.3.3
CAS number 37279-01-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methylglyoxal synthase (EC 4.2.3.3) is an enzyme that catalyzes the chemical reaction

glycerone phosphate \rightleftharpoons methylglyoxal + phosphate

Hence, this enzyme has one substrate, glycerone phosphate, and two products, methylglyoxal and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is glycerone-phosphate phosphate-lyase (methylglyoxal-forming). Other names in common use include methylglyoxal synthetase, and glycerone-phosphate phospho-lyase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1B93, 1EGH, 1IK4, 1S89, 1S8A, 1VMD, and 1WO8.

References

  • Cooper RA, Anderson A (1970). "The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli". FEBS. Lett. 11 (4): 273–276. doi:10.1016/0014-5793(70)80546-4. PMID 11945504. 
  • Hopper DJ, Cooper RA (1971). "The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis?". FEBS. Lett. 13 (4): 213–216. doi:10.1016/0014-5793(71)80538-0. PMID 11945670. 
  • Ray S, Ray M (1981). "Isolation of methylglyoxal synthase from goat liver". J. Biol. Chem. 256 (12): 6230–3. PMID 7240200. 
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