D-glutamate cyclase

D-glutamate cyclase
D-glutamate cyclase
Identifiers
EC number 4.2.1.48
CAS number 37290-80-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-glutamate cyclase (EC 4.2.1.48) is an enzyme that catalyzes the chemical reaction

D-glutamate \rightleftharpoons 5-oxo-D-proline + H2O

Hence, this enzyme has one substrate, D-glutamate, and two products, 5-oxo-D-proline and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming). This enzyme is also called D-glutamate hydro-lyase (cyclizing). This enzyme participates in d-glutamine and d-glutamate metabolism.

References

  • MEISTER A, BUKENBERGER MW, STRASSBURGER M (1963). "THE OPTICALLY-SPECIFIC ENZYMATIC CYCLIZATION OF D-GLUTAMATE". Biochem. Z. 338: 217–29. PMID 14087295. 
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