Citryl-CoA lyase

Citryl-CoA lyase
citryl-CoA lyase
Identifiers
EC number 4.1.3.34
CAS number 131095-35-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a citryl-CoA lyase (EC 4.1.3.34) is an enzyme that catalyzes the chemical reaction

(3S)-citryl-CoA \rightleftharpoons acetyl-CoA + oxaloacetate

Hence, this enzyme has one substrate, (3S)-citryl-CoA, and two products, acetyl-CoA and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming). This enzyme is also called (3S)-citryl-CoA oxaloacetate-lyase. This enzyme participates in citrate cycle (tca cycle).

References

  • Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80 (2): 479–88. doi:10.1111/j.1432-1033.1977.tb11903.x. PMID 336371. 
  • Lill U, Schreil A, Eggerer H (1982). "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 (3): 645–50. doi:10.1111/j.1432-1033.1982.tb06731.x. PMID 6749502. 
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