Proline racemase

In enzymology, a proline racemase (EC number|5.1.1.4) is an enzyme that catalyzes the chemical reaction

:L-proline $ightleftharpoons$ D-proline

Hence, this enzyme has one substrate, L-proline, and one product, D-proline.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is proline racemase. This enzyme participates in arginine and proline metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1TM0, PDB link|1W61, and PDB link|1W62.

References

* [http://www.jbc.org/cgi/reprint/228/2/983] cite journal | author = Stadtman TC and Elliott P | date = 1957 | title = Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii | journal = J. Biol. Chem. | volume = 228 | pages = 983–997
* [http://dx.doi.org/10.1021/jp7104105] cite journal | author = Stenta M, Calvaresi M, Altoè P, Spinelli D, Garavelli M and Bottoni A | date = 2008 | title = The Catalytic Activity of Proline Racemase: A Quantum Mechanical/Molecular Mechanical Study | journal = J. Chem. Phys. B | volume = 112 |issue = 4| pages = 1057–1059 | doi = 10.1021/jp7104105

External links

::"The CAS registry number for this enzyme class is CAS registry|9024-09-3."

Gene Ontology (GO) codes