Maleylacetoacetate isomerase

maleylacetoacetate isomerase
Identifiers
EC number	5.2.1.2
CAS number	9023-75-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a maleylacetoacetate isomerase (EC 5.2.1.2) is an enzyme that catalyzes the chemical reaction

4-maleylacetoacetate $\rightleftharpoons$ 4-fumarylacetoacetate

Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.

References

• EDWARDS SW, KNOX WE (1956). "Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione". J. Biol. Chem. 220 (1): 79–91. PMID 13319328. 
• Lack L (1961). "Enzymic cis-trans isomerization of maleylpyruvic acid". J. Biol. Chem. 236: 2835–2840. PMID 14461395. 
• Seltzer S (1973). "Purification and properties of maleylacetone cis-trans isomerase from vibrio 01". J. Biol. Chem. 248 (1): 215–22. PMID 4692831. 

This isomerase article is a stub. You can help Wikipedia by expanding it.v · Categories: Isomerase stubs EC 5.2.1 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Jeffrey Spieler GVI Look at other dictionaries: maleylacetoacetate isomerase — ma·le·yl·ace·to·ac·e·tate isom·er·ase (ma″le əl ə se″to asґə tāt i somґər ās) [EC 5.2.1.2] an enzyme of the isomerase class that catalyzes the interconversion of the isomers 4 maleylacetoacetate and 4… …   Medical dictionary maleylacetoacetate — An intermediate in l phenylalanine and l tyrosine catabolism; accumulates in certain inherited disorders of tyrosine metabolism. m. cis,trans isomerase an enzyme that catalyzes the reversible conversion of m. to 4 fumarylacetoacetate; an enzyme… …   Medical dictionary GSTZ1 — Glutathione transferase zeta 1 (maleylacetoacetate isomerase), also known as GSTZ1, is a human gene.cite web | title = Entrez Gene: GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)| url =… …   Wikipedia List of EC numbers (EC 5) — This list contains a list of EC numbers for the fifth group, EC 5, isomerases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. =EC 5.1: Epimerases and… …   Wikipedia Glutathione S-transferase, C-terminal domain — Pfam box Symbol = GST C Name = Glutathione S transferase, C terminal domain width = caption = Pfam= PF00043 InterPro= IPR004046 SMART= Prosite = SCOP = 2gst TCDB = OPM family= 139 OPM protein= 1z9h PDB=PDB3|1gnwA:111 206 PDB3|1bx9A:111 206… …   Wikipedia Tyrosine — NatOrganicBox name=( S ) 2 Amino 3 (4 hydroxyphenyl) propanoic acid PubChem = 1153 CAS = 60 18 4 SMILES = N [C@@H] (Cc1ccc(O)cc1)C(O)=O C=9 | H=11 | N=1 | O=3 mass=181.19 g/molTyrosine (abbreviated as Tyr or Y) [cite web | author=IUPAC IUBMB… …   Wikipedia 3-Phosphoglyceric acid — 3 Phosphoglyceric acid …   Wikipedia Proline — For other uses, see Proline (disambiguation). Proline …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”