GSTZ1

Glutathione transferase zeta 1 (maleylacetoacetate isomerase), also known as GSTZ1, is a human gene.cite web | title = Entrez Gene: GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2954| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.cite web | title = Entrez Gene: GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2954| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ketterer B |title=A bird's eye view of the glutathione transferase field. |journal=Chem. Biol. Interact. |volume=138 |issue= 1 |pages= 27–42 |year= 2001 |pmid= 11640913 |doi=
*cite journal | author=Board PG, Baker RT, Chelvanayagam G, Jermiin LS |title=Zeta, a novel class of glutathione transferases in a range of species from plants to humans. |journal=Biochem. J. |volume=328 ( Pt 3) |issue= |pages= 929–35 |year= 1998 |pmid= 9396740 |doi=
*cite journal | author=Fernández-Cañón JM, Peñalva MA |title=Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 329–37 |year= 1998 |pmid= 9417084 |doi=
*cite journal | author=Tong Z, Board PG, Anders MW |title=Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. |journal=Biochem. J. |volume=331 ( Pt 2) |issue= |pages= 371–4 |year= 1998 |pmid= 9531472 |doi=
*cite journal | author=Tong Z, Board PG, Anders MW |title=Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. |journal=Chem. Res. Toxicol. |volume=11 |issue= 11 |pages= 1332–8 |year= 1999 |pmid= 9815194 |doi= 10.1021/tx980144f
*cite journal | author=Blackburn AC, Woollatt E, Sutherland GR, Board PG |title=Characterization and chromosome location of the gene GSTZ1 encoding the human Zeta class glutathione transferase and maleylacetoacetate isomerase. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 109–14 |year= 1999 |pmid= 9925947 |doi=
*cite journal | author=Fernández-Cañón JM, Hejna J, Reifsteck C, "et al." |title=Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase. |journal=Genomics |volume=58 |issue= 3 |pages= 263–9 |year= 1999 |pmid= 10373324 |doi= 10.1006/geno.1999.5832
*cite journal | author=Blackburn AC, Tzeng HF, Anders MW, Board PG |title=Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. |journal=Pharmacogenetics |volume=10 |issue= 1 |pages= 49–57 |year= 2000 |pmid= 10739172 |doi=
*cite journal | author=Polekhina G, Board PG, Blackburn AC, Parker MW |title=Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. |journal=Biochemistry |volume=40 |issue= 6 |pages= 1567–76 |year= 2001 |pmid= 11327815 |doi=
*cite journal | author=Blackburn AC, Coggan M, Tzeng HF, "et al." |title=GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase. |journal=Pharmacogenetics |volume=11 |issue= 8 |pages= 671–8 |year= 2002 |pmid= 11692075 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Heilig R, Eckenberg R, Petit JL, "et al." |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ricci G, Turella P, De Maria F, "et al." |title=Binding and kinetic mechanisms of the Zeta class glutathione transferase. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33336–42 |year= 2004 |pmid= 15173170 |doi= 10.1074/jbc.M404631200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hui J, Hung LH, Heiner M, "et al." |title=Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. |journal=EMBO J. |volume=24 |issue= 11 |pages= 1988–98 |year= 2005 |pmid= 15889141 |doi= 10.1038/sj.emboj.7600677
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Fang YY, Kashkarov U, Anders MW, Board PG |title=Polymorphisms in the human glutathione transferase zeta promoter. |journal=Pharmacogenet. Genomics |volume=16 |issue= 5 |pages= 307–13 |year= 2006 |pmid= 16609361 |doi= 10.1097/01.fpc.0000205000.07054.b3

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