D-ornithine 4,5-aminomutase

D-ornithine 4,5-aminomutase
D-ornithine 4,5-aminomutase
Identifiers
EC number 5.4.3.5
CAS number 62213-30-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-ornithine 4,5-aminomutase (EC 5.4.3.5) is an enzyme that catalyzes the chemical reaction

D-ornithine \rightleftharpoons (2R,4S)-2,4-diaminopentanoate

Hence, this enzyme has one substrate, D-ornithine, and one product, (2R,4S)-2,4-diaminopentanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is D-ornithine 4,5-aminomutase. Other names in common use include D-alpha-ornithine 5,4-aminomutase, and D-ornithine aminomutase. This enzyme participates in d-arginine and d-ornithine metabolism. It has 3 cofactors: pyridoxal phosphate, Cobamide coenzyme, and Dithiothreitol.

References

  • Somack R, Costilow RN (1973). "Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5,4-aminomutase". Biochemistry. 12 (14): 2597–604. doi:10.1021/bi00738a008. PMID 4711468. 
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