Cycloartenol synthase

Cycloartenol synthase
cycloartenol synthase
Identifiers
EC number 5.4.99.8
CAS number 9075-25-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cycloartenol synthase (EC 5.4.99.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3-epoxysqualene \rightleftharpoons cycloartenol

Hence, this enzyme has one substrate, (S)-2,3-epoxysqualene, and one product, cycloartenol.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming). Other names in common use include 2,3-epoxysqualene cycloartenol-cyclase, squalene-2,3-epoxide-cycloartenol cyclase, 2,3-epoxysqualene cycloartenol-cyclase, 2,3-epoxysqualene-cycloartenol cyclase, and 2,3-oxidosqualene-cycloartenol cyclase. This enzyme participates in biosynthesis of steroids.

References

  • Rees HH, Goad LJ, Goodwin TW (1969). "2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis". Biochim. Biophys. Acta. 176 (4): 892–4. PMID 5797101. 
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