Prenyltransferase

Pfam_box
Symbol = Prenyltrans
Name = Prenyltransferase and squalene oxidase repeat


width =
caption =
Pfam= PF00432
InterPro= IPR001330
SMART=
PROSITE = PDOC00825
SCOP = 1sqc
TCDB =
OPM family=
OPM protein= 1w6k
PDB=PDB3|1w6kA:122-165 PDB3|1w6jA:122-165 PDB3|1o6qA:59-102PDB3|1umpC:59-102 PDB3|1h39A:59-102 PDB3|1h3cB:59-102PDB3|2sqcA:59-102 PDB3|1h37A:59-102 PDB3|1o6hA:59-102PDB3|1gszA:59-102 PDB3|3sqcA:59-102 PDB3|1o79A:59-102PDB3|1h35A:59-102 PDB3|1h3aC:59-102 PDB3|1h36A:59-102PDB3|1h3bA:59-102 PDB3|1o6rB:59-102 PDB3|1sqc :59-102PDB3|1s64L:142-186 PDB3|1tnuJ:142-186 PDB3|1n4qH:142-186PDB3|1n4pD:142-186 PDB3|1n4sL:142-186 PDB3|1n4rH:142-186PDB3|1tnzL:142-186 PDB3|1tnyL:142-186 PDB3|1tnbD:142-186PDB3|1tnoH:142-186 PDB3|1dceD:114-157 PDB3|1ltxB:114-157PDB3|1jcqB:172-215 PDB3|1mzcB:172-215 PDB3|1s63B:172-215PDB3|1sa4B:172-215 PDB3|1ld7B:172-215 PDB3|1ld8B:172-215PDB3|1tn6B:172-215 PDB3|2ftiB:172-215 PDB3|1fppB:172-215PDB3|1n9aB:172-215 PDB3|1nl4B:172-215 PDB3|1hz7B:172-215PDB3|1o5mB:172-215 PDB3|1n94B:172-215 PDB3|1kzoB:172-215PDB3|1jcrB:172-215 PDB3|1o1rB:172-215 PDB3|1ni1B:172-215PDB3|1sa5B:172-215 PDB3|1ftiB:172-215 PDB3|1qbqB:172-215PDB3|1d8dB:172-215 PDB3|1ft2B:172-215 PDB3|1ft1B:172-215PDB3|1o1sB:172-215 PDB3|1d8eB:172-215 PDB3|1tn8B:172-215PDB3|1qe2B:172-215 PDB3|1x81B:172-215 PDB3|1kzpB:172-215PDB3|1tn7B:172-215 PDB3|1kzrB:172-215 PDB3|1jcsB:172-215PDB3|3ftiB:172-215 PDB3|1o1tB:172-215 PDB3|1n95B:172-215

Prenyltransferases are a class of enzymes that transfer allylic prenyl groups to acceptor molecules. Prenyl transferases commonly refer to prenyl diphosphate synthases.cite journal | author = Takahashi S, Koyama T | title = Structure and function of cis-prenyl chain elongating enzymes | journal = Chem Rec | volume = 6 | issue = 4 | pages = 194–205 | year = 2006 | pmid = 16900467 | doi = 10.1002/tcr.20083 | url = | issn = ]

Prenyltransferases are commonly divided into two classes, cis (or Z) and trans (or E), depending upon the stereo chemistry of the resulting products. Examples of trans-prenyltranferases include dimethylallyltranstransferase, and geranylgeranyl pyrophosphate synthase. Cis-prenyltransferases include dehydrodolichol diphosphate synthase (involved in the production of a precursor to dolichol).

The beta subunit of the farnesyltransferases is responsible for peptide binding. Squalene-hopene cyclase is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid (triterpenoid) metabolism.cite journal |author=Schulz GE, Wendt KU, Poralla K |title=Structure and function of a squalene cyclase |journal=Science |volume=277 |issue=5333 |pages=1811–1815 |year=1997 |pmid=9295270 |doi=10.1126/science.277.5333.1811] Lanosterol synthase (EC number|5.4.99.7) (oxidosqualene-lanosterol cyclase) catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi.cite journal |author=Prestwich GD, Poralla K, Hewelt A, Abe I, Reipen I, Sprenger G |title=A specific amino acid repeat in squalene and oxidosqualene cyclases |journal=Trends Biochem. Sci. |volume=19 |issue=4 |pages=157–158 |year=1994 |pmid=8016864 |doi=10.1016/0968-0004(94)90276-3] Cycloartenol synthase (EC number| 5.4.99.8) (2,3-epoxysqualene-cycloartenol cyclase) is a plant enzyme that catalyzes the cyclization of (S)-2,3-epoxysqualene to cycloartenol.

Human proteins containing this domain

FNTB; LSS; PGGT1B; RABGGTB

References

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00703 Protein prenyltransferases alpha subunit repeat] in PROSITE

Further reading

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