ODC1

Ornithine decarboxylase 1
PDB rendering based on 1d7k.
Available structures PDB 1D7K, 2ON3, 2OO0
Identifiers
Symbols	ODC1;
External IDs	OMIM: 165640 MGI: 97402 HomoloGene: 1906 GeneCards: ODC1 Gene
EC number	4.1.1.17
Gene Ontology Molecular function • ornithine decarboxylase activity • protein binding • lyase activity Cellular component • cellular_component • cytosol Biological process • regulation of cellular amino acid metabolic process • polyamine metabolic process • polyamine biosynthetic process • response to virus • cellular nitrogen compound metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4953	18263
Ensembl	ENSG00000115758	ENSMUSG00000011179
UniProt	P11926	Q3TM76
RefSeq (mRNA)	NM_002539.1	NM_013614.2
RefSeq (protein)	NP_002530.1	NP_038642.2
Location (UCSC)	Chr 2: 10.58 – 10.59 Mb	Chr 12: 17.55 – 17.56 Mb
PubMed search	[1]	[2]

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.^[1]

References

1. ^ "Entrez Gene: ODC1 ornithine decarboxylase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4953. 

Further reading

• Pegg AE (2006). "Regulation of ornithine decarboxylase.". J. Biol. Chem. 281 (21): 14529–32. doi:10.1074/jbc.R500031200. PMID 16459331. 
• Yoshida M, Hayashi H, Taira M, Isono K (1992). "Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.". Cancer Res. 52 (23): 6671–5. PMID 1423312. 
• Moshier JA, Osborne DL, Skunca M, et al. (1992). "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.". Nucleic Acids Res. 20 (10): 2581–90. doi:10.1093/nar/20.10.2581. PMC 312396. PMID 1598217. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312396. 
• Hickok NJ, Wahlfors J, Crozat A, et al. (1990). "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.". Gene 93 (2): 257–63. doi:10.1016/0378-1119(90)90233-H. PMID 2227439. 
• Hsieh JT, Denning MF, Heidel SM, Verma AK (1990). "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.". Cancer Res. 50 (8): 2239–44. PMID 2317811. 
• Moshier JA, Gilbert JD, Skunca M, et al. (1990). "Isolation and expression of a human ornithine decarboxylase gene.". J. Biol. Chem. 265 (9): 4884–92. PMID 2318872. 
• Verrando P, Juhlin L, Lacour JP, Ortonne JP (1987). "Immunohistochemical localization of ornithine decarboxylase in human skin.". J. Dermatol. 14 (2): 112–7. PMID 2440930. 
• van Steeg H, van Oostrom CT, Martens JW, et al. (1989). "Nucleotide sequence of the human ornithine decarboxylase gene.". Nucleic Acids Res. 17 (21): 8855–6. doi:10.1093/nar/17.21.8855. PMC 335049. PMID 2587220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335049. 
• Fitzgerald MC, Flanagan MA (1990). "Characterization and sequence analysis of the human ornithine decarboxylase gene.". DNA 8 (9): 623–34. PMID 2693021. 
• Alhonen-Hongisto L, Leinonen P, Sinervirta R, et al. (1987). "Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.". Biochem. J. 242 (1): 205–10. PMC 1147684. PMID 3036086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1147684. 
• Kaczmarek L, Calabretta B, Ferrari S, de Riel JK (1987). "Cell-cycle-dependent expression of human ornithine decarboxylase.". J. Cell. Physiol. 132 (3): 545–51. doi:10.1002/jcp.1041320318. PMID 3308908. 
• Hickok NJ, Seppänen PJ, Gunsalus GL, Jänne OA (1987). "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.". DNA 6 (3): 179–87. doi:10.1089/dna.1987.6.179. PMID 3595418. 
• Winqvist R, Mäkelä TP, Seppänen P, et al. (1986). "Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.". Cytogenet. Cell Genet. 42 (3): 133–40. doi:10.1159/000132266. PMID 3755388. 
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789. 
• Kim YJ, Pan H, Verma AK (1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene.". Mol. Carcinog. 10 (3): 169–79. doi:10.1002/mc.2940100308. PMID 8043198. 
• Müller M, Pajunen AE, Järvinen M, et al. (1994). "Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain.". Dev. Neurosci. 15 (2): 87–93. doi:10.1159/000111320. PMID 8168440. 
• Ichiba T, Matsufuji S, Miyazaki Y, et al. (1994). "Functional regions of ornithine decarboxylase antizyme.". Biochem. Biophys. Res. Commun. 200 (3): 1721–7. doi:10.1006/bbrc.1994.1651. PMID 8185631. 
• Wright PS, Cooper JR, Cross-Doersen DE, et al. (1996). "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.". Cell Growth Differ. 6 (9): 1097–102. PMID 8519686. 
• Heiskala M, Zhang J, Hayashi S, et al. (1999). "Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation.". EMBO J. 18 (5): 1214–22. doi:10.1093/emboj/18.5.1214. PMC 1171212. PMID 10064588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171212. 
• Pomidor MM, Cimildoro R, Lazatin B, et al. (2000). "Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins.". Mol. Biol. Cell 10 (12): 4299–310. PMC 25759. PMID 10588659. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25759.