ODC1

ODC1
Ornithine decarboxylase 1

PDB rendering based on 1d7k.
Identifiers
Symbols ODC1;
External IDs OMIM165640 MGI97402 HomoloGene1906 GeneCards: ODC1 Gene
EC number 4.1.1.17
RNA expression pattern
PBB GE ODC1 200790 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4953 18263
Ensembl ENSG00000115758 ENSMUSG00000011179
UniProt P11926 Q3TM76
RefSeq (mRNA) NM_002539.1 NM_013614.2
RefSeq (protein) NP_002530.1 NP_038642.2
Location (UCSC) Chr 2:
10.58 – 10.59 Mb
Chr 12:
17.55 – 17.56 Mb
PubMed search [1] [2]

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.[1]

References

Further reading


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