- AP2A1
Adaptor-related protein complex 2, alpha 1 subunit, also known as AP2A1, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.cite web | title = Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue= |pages= 699–727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699
*cite journal | author=Robinson MS |title=Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). |journal=J. Cell Biol. |volume=108 |issue= 3 |pages= 833–42 |year= 1989 |pmid= 2564002 |doi=
*cite journal | author=Goodman OB, Keen JH |title=The alpha chain of the AP-2 adaptor is a clathrin binding subunit. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23768–73 |year= 1995 |pmid= 7559550 |doi=
*cite journal | author=Page LJ, Robinson MS |title=Targeting signals and subunit interactions in coated vesicle adaptor complexes. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 619–30 |year= 1995 |pmid= 7593184 |doi=
*cite journal | author=Li C, Ullrich B, Zhang JZ, "et al." |title=Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. |journal=Nature |volume=375 |issue= 6532 |pages= 594–9 |year= 1995 |pmid= 7791877 |doi= 10.1038/375594a0
*cite journal | author=Okabayashi Y, Sugimoto Y, Totty NF, "et al." |title=Interaction of Shc with adaptor protein adaptins. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5265–9 |year= 1996 |pmid= 8617812 |doi=
*cite journal | author=Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N |title=The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 12111–6 |year= 1996 |pmid= 8662627 |doi=
*cite journal | author=van Delft S, Schumacher C, Hage W, "et al." |title=Association and colocalization of Eps15 with adaptor protein-2 and clathrin. |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 811–21 |year= 1997 |pmid= 9049247 |doi=
*cite journal | author=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319–22 |year= 1997 |pmid= 9280305 |doi=
*cite journal | author=Chen H, Fre S, Slepnev VI, "et al." |title=Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. |journal=Nature |volume=394 |issue= 6695 |pages= 793–7 |year= 1998 |pmid= 9723620 |doi= 10.1038/29555
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Hussain NK, Yamabhai M, Ramjaun AR, "et al." |title=Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15671–7 |year= 1999 |pmid= 10336464 |doi=
*cite journal | author=Tebar F, Bohlander SK, Sorkin A |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. |journal=Mol. Biol. Cell |volume=10 |issue= 8 |pages= 2687–702 |year= 1999 |pmid= 10436022 |doi=
*cite journal | author=Vleurick L, Pezet A, Kühn ER, "et al." |title=A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha-adaptin association. |journal=Mol. Endocrinol. |volume=13 |issue= 11 |pages= 1823–31 |year= 1999 |pmid= 10551776 |doi=
*cite journal | author=Fan GH, Yang W, Wang XJ, "et al." |title=Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. |journal=Biochemistry |volume=40 |issue= 3 |pages= 791–800 |year= 2001 |pmid= 11170396 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Sakaguchi K, Okabayashi Y, Kasuga M |title=Shc mediates ligand-induced internalization of epidermal growth factor receptors. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 5 |pages= 1154–60 |year= 2001 |pmid= 11302736 |doi= 10.1006/bbrc.2001.4680
*cite journal | author=Crump CM, Xiang Y, Thomas L, "et al." |title=PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2191–201 |year= 2001 |pmid= 11331585 |doi= 10.1093/emboj/20.9.2191
*cite journal | author=Rotem-Yehudar R, Galperin E, Horowitz M |title=Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33054–60 |year= 2001 |pmid= 11423532 |doi= 10.1074/jbc.M009913200PBB_Controls
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