MT-ND3

NADH dehydrogenase, subunit 3 (complex I)
Identifiers
Symbols	ND3; MTND3
External IDs	OMIM: 516002 MGI: 102499 HomoloGene: 5018 GeneCards: ND3 Gene
Gene Ontology Molecular function • NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex I • mitochondrial respiratory chain complex I • membrane • integral to membrane • respiratory chain Biological process • mitochondrial electron transport, NADH to ubiquinone • transport • response to oxidative stress • response to light intensity • response to hormone stimulus • respiratory electron transport chain Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4537	17718
Ensembl	ENSG00000198840	ENSMUSG00000064360
UniProt	P03897	Q7GIP5
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	YP_003024033.1	NP_904335.1
Location (UCSC)	Chr MT: 0.01 – 0.01 Mb	Chr MT: 0.01 – 0.01 Mb
PubMed search	[1]	[2]

NADH-ubiquinone oxidoreductase chain 3 is an enzyme that in humans is encoded by the MT-ND3 gene.^[1]

References

1. ^ "Entrez Gene: ND3 NADH dehydrogenase subunit 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4537. 

Further reading

• Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339–45. doi:10.1016/j.tig.2006.04.001. PMID 16678300. 
• Horai S, Hayasaka K, Kondo R, et al. (1995). "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.". Proc. Natl. Acad. Sci. U.S.A. 92 (2): 532–6. doi:10.1073/pnas.92.2.532. PMC 42775. PMID 7530363. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42775. 
• Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708–13. doi:10.1038/35047064. PMID 11130070. 
• Finnilä S, Lehtonen MS, Majamaa K (2001). "Phylogenetic network for European mtDNA.". Am. J. Hum. Genet. 68 (6): 1475–84. doi:10.1086/320591. PMC 1226134. PMID 11349229. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1226134. 
• Maca-Meyer N, González AM, Larruga JM, et al. (2003). "Major genomic mitochondrial lineages delineate early human expansions.". BMC Genet. 2: 13. doi:10.1186/1471-2156-2-13. PMC 55343. PMID 11553319. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55343. 
• Herrnstadt C, Elson JL, Fahy E, et al. (2002). "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.". Am. J. Hum. Genet. 70 (5): 1152–71. doi:10.1086/339933. PMC 447592. PMID 11938495. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=447592. 
• Silva WA, Bonatto SL, Holanda AJ, et al. (2002). "Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America.". Am. J. Hum. Genet. 71 (1): 187–92. doi:10.1086/341358. PMC 384978. PMID 12022039. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384978. 
• Sudoyo H, Suryadi H, Lertrit P, et al. (2003). "Asian-specific mtDNA backgrounds associated with the primary G11778A mutation of Leber's hereditary optic neuropathy.". J. Hum. Genet. 47 (11): 594–604. doi:10.1007/s100380200091. PMID 12436196. 
• Mishmar D, Ruiz-Pesini E, Golik P, et al. (2003). "Natural selection shaped regional mtDNA variation in humans.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 171–6. doi:10.1073/pnas.0136972100. PMC 140917. PMID 12509511. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140917. 
• Ingman M, Gyllensten U (2003). "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.". Genome Res. 13 (7): 1600–6. doi:10.1101/gr.686603. PMC 403733. PMID 12840039. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403733. 
• Kong QP, Yao YG, Sun C, et al. (2003). "Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.". Am. J. Hum. Genet. 73 (3): 671–6. doi:10.1086/377718. PMC 1180693. PMID 12870132. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180693. 
• Moilanen JS, Finnila S, Majamaa K (2004). "Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.". Mol. Biol. Evol. 20 (12): 2132–42. doi:10.1093/molbev/msg230. PMID 12949126. 
• Coble MD, Just RS, O'Callaghan JE, et al. (2004). "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.". Int. J. Legal Med. 118 (3): 137–46. doi:10.1007/s00414-004-0427-6. PMID 14760490. 
• Crimi M, Papadimitriou A, Galbiati S, et al. (2004). "A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality.". Pediatr. Res. 55 (5): 842–6. doi:10.1203/01.PDR.0000117844.73436.68. PMID 14764913. 
• Tanaka M, Cabrera VM, González AM, et al. (2004). "Mitochondrial genome variation in eastern Asia and the peopling of Japan.". Genome Res. 14 (10A): 1832–50. doi:10.1101/gr.2286304. PMC 524407. PMID 15466285. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524407. 
• Palanichamy MG, Sun C, Agrawal S, et al. (2005). "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia.". Am. J. Hum. Genet. 75 (6): 966–78. doi:10.1086/425871. PMC 1182158. PMID 15467980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1182158. 
• Starikovskaya EB, Sukernik RI, Derbeneva OA, et al. (2005). "Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups.". Ann. Hum. Genet. 69 (Pt 1): 67–89. doi:10.1046/j.1529-8817.2003.00127.x. PMID 15638829. 
• Achilli A, Rengo C, Battaglia V, et al. (2005). "Saami and Berbers--an unexpected mitochondrial DNA link.". Am. J. Hum. Genet. 76 (5): 883–6. doi:10.1086/430073. PMC 1199377. PMID 15791543. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1199377. 
• Rajkumar R, Banerjee J, Gunturi HB, et al. (2006). "Phylogeny and antiquity of M macrohaplogroup inferred from complete mt DNA sequence of Indian specific lineages.". BMC Evol. Biol. 5: 26. doi:10.1186/1471-2148-5-26. PMC 1079809. PMID 15804362. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1079809. 
• Friedlaender J, Schurr T, Gentz F, et al. (2005). "Expanding Southwest Pacific mitochondrial haplogroups P and Q.". Mol. Biol. Evol. 22 (6): 1506–17. doi:10.1093/molbev/msi142. PMID 15814828. 

External links

• GeneReviews/NCBI/NIH/UW entry on Mitochondrial DNA-Associated Leigh Syndrome and NARP