Protein-disulfide reductase

In enzymology, a protein-disulfide reductase (EC number|1.8.1.8) is an enzyme that catalyzes the chemical reaction

:protein dithiol + NAD(P)+ $ightleftharpoons$ protein disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are protein dithiol, NAD⁺, and NADP⁺, whereas its 4 products are protein disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is protein-dithiol:NAD(P)+ oxidoreductase. Other names in common use include protein disulphide reductase, insulin-glutathione transhydrogenase, disulfide reductase, and NAD(P)H2:protein-disulfide oxidoreductase.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1UC7, PDB link|1VRS, PDB link|1Z5Y, PDB link|2FWE, PDB link|2FWF, PDB link|2FWG, PDB link|2FWH, and PDB link|2PPT.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9029-19-0."

Gene Ontology (GO) codes