N-hydroxy-2-acetamidofluorene reductase

N-hydroxy-2-acetamidofluorene reductase
N-hydroxy-2-acetamidofluorene reductase
Identifiers
EC number 1.7.1.12
CAS number 99890-08-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction

2-acetamidofluorene + NAD(P)+ + H2O \rightleftharpoons N-hydroxy-2-acetamidofluorene + NAD(P)H + H+

The 4 substrates of this enzyme are 2-acetamidofluorene, NAD+, NADP+, and H2O, whereas its 4 products are N-hydroxy-2-acetamidofluorene, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N-hydroxy-2-acetylaminofluorene reductase, and NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase.

References

  • Gutmann HR, Erickson RR (1969). "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction". J. Biol. Chem. 244 (7): 1729–40. PMID 5780838. 
  • Kitamura S, Tatsumi K (1985). "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. Biophys. Res. Commun. 133 (1): 67–74. doi:10.1016/0006-291X(85)91842-X. PMID 4074379. 
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