- L-amino-acid oxidase
In
enzymology , a L-amino-acid oxidase (EC number|1.4.3.2) is anenzyme that catalyzes thechemical reaction :an L-amino acid + H2O + O2 a 2-oxo acid + NH3 + H2O2
The 3 substrates of this enzyme are L-
amino acid , H2O, and O2, whereas its 3 products are2-oxo acid , NH3, and H2O2.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-amino-acid:oxygen oxidoreductase (deaminating). This enzyme is also called ophio-amino-acid oxidase. This enzyme participates in 8 metabolic pathways:alanine andaspartate metabolism,methionine metabolism,valine ,leucine andisoleucine degradation,tyrosine metabolism,phenylalanine metabolism,tryptophan metabolism,phenylalanine ,tyrosine andtryptophan biosynthesis, andalkaloid biosynthesis. It employs one cofactor,FAD .tructural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1F8R, PDB link|1F8S, PDB link|1REO, PDB link|1TDK, PDB link|1TDN, PDB link|1TDO, PDB link|2IID, PDB link|2JAE, PDB link|2JB1, PDB link|2JB2, and PDB link|2JB3.
References
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 609-648.
*External links
::"The
CAS registry number for this enzyme class is CAS registry|9000-89-9."Gene Ontology (GO) codes
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