D-octopine dehydrogenase

D-octopine dehydrogenase
D-octopine dehydrogenase
Identifiers
EC number 1.5.1.11
CAS number 37256-27-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-octopine dehydrogenase (EC 1.5.1.11) is an enzyme that catalyzes the chemical reaction

N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O \rightleftharpoons L-arginine + pyruvate + NADH + H+

The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-arginine, NAD+, and H2O, whereas its 4 products are L-arginine, pyruvate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming). Other names in common use include D-octopine synthase, octopine dehydrogenase, octopine:NAD+ oxidoreductase, ODH, 2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase, and (L-arginine-forming). This enzyme participates in arginine and proline metabolism.

References

  • Kemp JD, Hack E, Sutton DW and El-Wakil M (1979). "Unusual amino acids and their relationship to tumorigenesis". Proc. Int. Conf. Plant Pathol. Bact. 4th: 183–188. 
  • van Thoai N, Huc C, Pho DB, Olomucki A (1969). "[Octopine dehydrogenase. Purification and catalytic properties]". Biochim. Biophys. Acta. 191 (1): 46–57. PMID 4310628. 
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