Cytokinin dehydrogenase

Cytokinin dehydrogenase
cytokinin dehydrogenase
Identifiers
EC number 1.5.99.12
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cytokinin dehydrogenase (EC 1.5.99.12) is an enzyme that catalyzes the chemical reaction

N6-dimethylallyladenine + acceptor + H2O \rightleftharpoons adenine + 3-methylbut-2-enal + reduced acceptor

The 3 substrates of this enzyme are N6-dimethylallyladenine, acceptor, and H2O, whereas its 3 products are adenine, 3-methylbut-2-enal, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N6-dimethylallyladenine:acceptor oxidoreductase. Other names in common use include N6-dimethylallyladenine:(acceptor) oxidoreductase, 6-N-dimethylallyladenine:acceptor oxidoreductase, OsCKX2, CKX, and cytokinin oxidase/dehydrogenase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1W1O, 1W1Q, 1W1R, 1W1S, 2EXR, and 2Q4W.

References

  • Galuszka P, Frebort I, Sebela M, Sauer P, Jacobsen S, Pec P (2001). "Cytokinin oxidase or dehydrogenase? Mechanism of cytokinin degradation in cereals". Eur. J. Biochem. 268 (2): 450–461. doi:10.1046/j.1432-1033.2001.01910.x. PMID 11168382. 
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