Oxalate oxidase

Oxalate oxidase
oxalate oxidase
Identifiers
EC number 1.2.3.4
CAS number 9031-79-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an oxalate oxidase (EC 1.2.3.4) is an enzyme that catalyzes the chemical reaction

oxalate + O2 + 2 H+ \rightleftharpoons 2 CO2 + H2O2

The 3 substrates of this enzyme are oxalate, O2, and H+, whereas its two products are CO2 and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is oxalate:oxygen oxidoreductase. Other names in common use include aero-oxalo dehydrogenase, and oxalic acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It has 2 cofactors: FAD, and Manganese.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1FI2, 2ET1, 2ET7, and 2ETE.

References