Malonate-semialdehyde dehydrogenase

Malonate-semialdehyde dehydrogenase
Malonate-semialdehyde dehydrogenase
Identifiers
EC number 1.2.1.15
CAS number 9028-94-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a malonate-semialdehyde dehydrogenase (EC 1.2.1.15) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + NAD(P)+ + H2O \rightleftharpoons malonate + NAD(P)H + 2 H+

The 4 substrates of this enzyme are 3-oxopropanoate, NAD+, NADP+, and H2O, whereas its 4 products are malonate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase. This enzyme participates in beta-alanine metabolism.

References

  • Nakamura K and Bernheim F (1961). "Studies on malonic semialdehyde dehydrogenase from Pseudomonas aeruginosa". Biochim. Biophys. Acta 50: 147–152. doi:10.1016/0006-3002(61)91071-X. PMID 13727610. 
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