Formaldehyde dehydrogenase

In enzymology, a formaldehyde dehydrogenase (EC number|1.2.1.46) is an enzyme that catalyzes the chemical reaction

:formaldehyde + NAD⁺ + H₂O $ightleftharpoons$ formate + NADH + 2 H⁺

The 3 substrates of this enzyme are formaldehyde, NAD⁺, and H₂O, whereas its 3 products are formate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formaldehyde:NAD+ oxidoreductase. Other names in common use include NAD+-linked formaldehyde dehydrogenase, and NAD+-dependent formaldehyde dehydrogenase. This enzyme participates in methane metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1KOL.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-84-6."

Gene Ontology (GO) codes