Mycothiol-dependent formaldehyde dehydrogenase

Mycothiol-dependent formaldehyde dehydrogenase
mycothiol-dependent formaldehyde dehydrogenase
Identifiers
EC number 1.2.1.66
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mycothiol-dependent formaldehyde dehydrogenase (EC 1.2.1.66) is an enzyme that catalyzes the chemical reaction

formaldehyde + mycothiol + NAD+ \rightleftharpoons S-formylmycothiol + NADH + 2 H+

The 3 substrates of this enzyme are formaldehyde, mycothiol, and NAD+, whereas its 3 products are S-formylmycothiol, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formaldehyde:NAD+ oxidoreductase (mycothiol-formylating). This enzyme is also called NAD/factor-dependent formaldehyde dehydrogenase.

References

  • Misset-Smits M, van Ophem PW, Sakuda S, Duine JA (1997). "Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl) -D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase". FEBS. Lett. 409 (2): 221–2. doi:10.1016/S0014-5793(97)00510-3. PMID 9202149. 
  • Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H (1997). "Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations". Eur. J. Biochem. 248 (2): 282–9. doi:10.1111/j.1432-1033.1997.00282.x. PMID 9346279. 
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