Dehydrogluconate dehydrogenase

Dehydrogluconate dehydrogenase
dehydrogluconate dehydrogenase
Identifiers
EC number 1.1.99.4
CAS number 9028-82-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dehydrogluconate dehydrogenase (EC 1.1.99.4) is an enzyme that catalyzes the chemical reaction

2-dehydro-D-gluconate + acceptor \rightleftharpoons 2,5-didehydro-D-gluconate + reduced acceptor

Thus, the two substrates of this enzyme are 2-dehydro-D-gluconate and acceptor, whereas its two products are 2,5-didehydro-D-gluconate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is 2-dehydro-D-gluconate:acceptor 2-oxidoreductase. Other names in common use include ketogluconate dehydrogenase, alpha-ketogluconate dehydrogenase, 2-keto-D-gluconate dehydrogenase, and 2-oxogluconate dehydrogenase. It has 2 cofactors: FAD, and Flavoprotein.

References

  • DATTA AG, KATZNELSON H (1956). "The oxidation of 2-ketogluconate by a partially purified enzyme from Acetobactor melanogenum". Arch. Biochem. Biophys. 65 (2): 576–8. doi:10.1016/0003-9861(56)90218-1. PMID 13395514. 
  • Shinagawa E and Ameyama M (1982). "2-Keto-D-gluconate dehydrogenase from Gluconobacter melanogenus, membrane-bound". Methods Enzymol. 89: 194–198. doi:10.1016/S0076-6879(82)89034-4. 
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