PON1

PON1

Paraoxonase 1 (PON1) is a protein-coding gene.cite journal | author = Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN | title = The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family | journal = Genomics | volume = 33 | issue = 3 | pages = 498–507 | year = 1996 | month = May | pmid = 8661009 | doi = 10.1006/geno.1996.0225 | url = | issn = ] The protein encoded by this gene has esterase activity.cite journal | author = van Himbergen TM, van Tits LJ, Roest M, Stalenhoef AF | title = The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine | journal = Neth J Med | volume = 64 | issue = 2 | pages = 34–8 | year = 2006 | month = February | pmid = 16517986 | doi = | url = http://www.zuidencomm.nl/njm/getarticle.php?v=64&i=2&p=34 | issn = ]

Function

PON1 is responsible for hydrolyising organophosphate pesticides and nerve gasses.

PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL).cite journal | author=Getz GS, Reardon CA |title=Paraoxonase, a cardioprotective enzyme: continuing issues. |journal=Curr. Opin. Lipidol. |volume=15 |issue= 3 |pages= 261–7 |year= 2005 |pmid= 15166781 |doi= ] cite journal | author=Mackness M, Mackness B |title=Paraoxonase 1 and atherosclerosis: is the gene or the protein more important? |journal=Free Radic. Biol. Med. |volume=37 |issue= 9 |pages= 1317–23 |year= 2005 |pmid= 15454272 |doi= 10.1016/j.freeradbiomed.2004.07.034 ]

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References

Further reading

PBB_Further_reading
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*cite journal | author=Furlong CE, Costa LG, Hassett C, "et al." |title=Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. |journal=Chem. Biol. Interact. |volume=87 |issue= 1-3 |pages= 35–48 |year= 1993 |pmid= 8393745 |doi=
*cite journal | author=Furlong CE, Cole TB, Jarvik GP, Costa LG |title=Pharmacogenomic considerations of the paraoxonase polymorphisms. |journal=Pharmacogenomics |volume=3 |issue= 3 |pages= 341–8 |year= 2002 |pmid= 12052142 |doi= 10.1517/14622416.3.3.341
*cite journal | author=Mackness B, Durrington PN, Mackness MI |title=The paraoxonase gene family and coronary heart disease. |journal=Curr. Opin. Lipidol. |volume=13 |issue= 4 |pages= 357–62 |year= 2003 |pmid= 12151850 |doi=
*cite journal | author=Costa LG, Cole TB, Furlong CE |title=Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. |journal=J. Toxicol. Clin. Toxicol. |volume=41 |issue= 1 |pages= 37–45 |year= 2003 |pmid= 12645966 |doi=
*cite journal | author=Furlong CE, Cole TB, Jarvik GP, "et al." |title=Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. |journal=Neurotoxicology |volume=26 |issue= 4 |pages= 651–9 |year= 2005 |pmid= 16112327 |doi= 10.1016/j.neuro.2004.08.002

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