PON3

Paraoxonase 3, also known as PON3, is a human gene.cite web | title = Entrez Gene: PON3 paraoxonase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.cite web | title = Entrez Gene: PON3 paraoxonase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mackness B, Durrington PN, Mackness MI |title=The paraoxonase gene family and coronary heart disease. |journal=Curr. Opin. Lipidol. |volume=13 |issue= 4 |pages= 357–62 |year= 2003 |pmid= 12151850 |doi=
*cite journal | author=Ng CJ, Shih DM, Hama SY, "et al." |title=The paraoxonase gene family and atherosclerosis. |journal=Free Radic. Biol. Med. |volume=38 |issue= 2 |pages= 153–63 |year= 2005 |pmid= 15607899 |doi= 10.1016/j.freeradbiomed.2004.09.035
*cite journal | author=Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN |title=The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. |journal=Genomics |volume=33 |issue= 3 |pages= 498–507 |year= 1996 |pmid= 8661009 |doi=
*cite journal | author=La Du BN |title=Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis? |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 467–8 |year= 2001 |pmid= 11304457 |doi=
*cite journal | author=Reddy ST, Wadleigh DJ, Grijalva V, "et al." |title=Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 4 |pages= 542–7 |year= 2001 |pmid= 11304470 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Aharoni A, Gaidukov L, Yagur S, "et al." |title=Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 2 |pages= 482–7 |year= 2004 |pmid= 14695884 |doi= 10.1073/pnas.2536901100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin P, Fu GK, Wilson AD, "et al." |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Draganov DI, Teiber JF, Speelman A, "et al." |title=Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. |journal=J. Lipid Res. |volume=46 |issue= 6 |pages= 1239–47 |year= 2005 |pmid= 15772423 |doi= 10.1194/jlr.M400511-JLR200
*cite journal | author=Shamir R, Hartman C, Karry R, "et al." |title=Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2. |journal=Free Radic. Biol. Med. |volume=39 |issue= 3 |pages= 336–44 |year= 2005 |pmid= 15993332 |doi= 10.1016/j.freeradbiomed.2005.03.016
*cite journal | author=Lu H, Zhu J, Zang Y, "et al." |title=Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product. |journal=Biochem. Pharmacol. |volume=70 |issue= 7 |pages= 1019–25 |year= 2005 |pmid= 16099434 |doi= 10.1016/j.bcp.2005.07.004
*cite journal | author=Lu H, Zhu J, Zang Y, "et al." |title=Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization. |journal=Protein Expr. Purif. |volume=46 |issue= 1 |pages= 92–9 |year= 2006 |pmid= 16139510 |doi= 10.1016/j.pep.2005.07.021
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065

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