PI4KA

Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide, also known as PIK4CA, is a human gene.cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gehrmann T, Heilmeyer LM |title=Phosphatidylinositol 4-kinases. |journal=Eur. J. Biochem. |volume=253 |issue= 2 |pages= 357–70 |year= 1998 |pmid= 9654085 |doi=
*cite journal | author=Graziani A, Ling LE, Endemann G, "et al." |title=Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. |journal=Biochem. J. |volume=284 ( Pt 1) |issue= |pages= 39–45 |year= 1992 |pmid= 1318025 |doi=
*cite journal | author=Kauffmann-Zeh A, Thomas GM, Ball A, "et al." |title=Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling. |journal=Science |volume=268 |issue= 5214 |pages= 1188–90 |year= 1995 |pmid= 7761838 |doi=
*cite journal | author=Wong K, Cantley LC |title=Cloning and characterization of a human phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 28878–84 |year= 1994 |pmid= 7961848 |doi=
*cite journal | author=Prasad KV, Kapeller R, Janssen O, "et al." |title=Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7708–17 |year= 1994 |pmid= 8246987 |doi=
*cite journal | author=Nakagawa T, Goto K, Kondo H |title=Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 12088–94 |year= 1996 |pmid= 8662589 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174–80 |year= 1997 |pmid= 9360995 |doi=
*cite journal | author=Gehrmann T, Gülkan H, Suer S, "et al." |title=Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230. |journal=Biochim. Biophys. Acta |volume=1437 |issue= 3 |pages= 341–56 |year= 1999 |pmid= 10101268 |doi=
*cite journal | author=Huang C, Handlogten ME, Miller RT |title=Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20293–300 |year= 2002 |pmid= 11907035 |doi= 10.1074/jbc.M200831200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Subrahmanyam G, Rudd CE, Schneider H |title=Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. |journal=Eur. J. Immunol. |volume=33 |issue= 1 |pages= 46–52 |year= 2003 |pmid= 12594831 |doi= 10.1002/immu.200390006
*cite journal | author=Carloni V, Mazzocca A, Ravichandran KS |title=Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. |journal=Oncogene |volume=23 |issue= 8 |pages= 1566–74 |year= 2004 |pmid= 14676841 |doi= 10.1038/sj.onc.1207287
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ahn J, Chung KS, Kim DU, "et al." |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741–8 |year= 2005 |pmid= 15607035 |doi=
*cite journal | author=Weixel KM, Blumental-Perry A, Watkins SC, "et al." |title=Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10501–8 |year= 2005 |pmid= 15634669 |doi= 10.1074/jbc.M414304200
*cite journal | author=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen. |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311–8 |year= 2005 |pmid= 15711748 |doi= 10.1267/THRO05020311
*cite journal | author=Waugh MG, Minogue S, Chotai D, "et al." |title=Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3757–63 |year= 2006 |pmid= 16249177 |doi= 10.1074/jbc.M506527200

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