- Thymine dioxygenase
In
enzymology , a thymine dioxygenase (EC number|1.14.11.6) is anenzyme that catalyzes thechemical reaction :thymine + 2-oxoglutarate + O2 5-hydroxymethyluracil + succinate + CO2
The 3 substrates of this enzyme are
thymine ,2-oxoglutarate , and O2, whereas its 3 products are5-hydroxymethyluracil ,succinate , and CO2.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating). Other names in common use include thymine 7-hydroxylase, 5-hydroxy-methyluracil dioxygenase, and 5-hydroxymethyluracil oxygenase. It has 2 cofactors:iron , andAscorbate .References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|37256-67-0."Gene Ontology (GO) codes
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