(-)-menthol monooxygenase

(-)-menthol monooxygenase
(-)-menthol monooxygenase
Identifiers
EC number 1.14.13.46
CAS number 117590-75-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (-)-menthol monooxygenase (EC 1.14.13.46) is an enzyme that catalyzes the chemical reaction

(-)-menthol + NADPH + H+ + O2 \rightleftharpoons p-menthane-3,8-diol + NADP+ + H2O

The 4 substrates of this enzyme are (-)-menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.

References

  • Madyastha KM, Srivatsan V (1988). "Studies on the metabolism of l-menthol in rats". Drug. Metab. Dispos. 16 (5): 765–72. PMID 2906604. 


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