Columbamine oxidase

Columbamine oxidase
columbamine oxidase
Identifiers
EC number 1.21.3.2
CAS number 95329-18-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a columbamine oxidase (EC 1.21.3.2) is an enzyme that catalyzes the chemical reaction

2 columbamine + O2 \rightleftharpoons 2 berberine + 2 H2O

Thus, the two substrates of this enzyme are columbamine and O2, whereas its two products are berberine and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with oxygen as acceptor. The systematic name of this enzyme class is columbamine:oxygen oxidoreductase (cyclizing). This enzyme is also called berberine synthase. This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, iron.

References

  • Rueffer M and Zenk MH (1985). "Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis". Tetrahedron Lett. 26 (2): 201–202. doi:10.1016/S0040-4039(00)61879-8. 
This EC 1.21 enzyme-related article is a stub. You can help Wikipedia by expanding it.