Orotate reductase (NADH)

orotate reductase (NADH)
Identifiers
EC number	1.3.1.14
CAS number	37255-26-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, an orotate reductase (NADH) (EC 1.3.1.14) is an enzyme that catalyzes the chemical reaction

(S)-dihydroorotate + NAD⁺ $\rightleftharpoons$ orotate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NAD⁺, whereas its 3 products are orotate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NAD+ oxidoreductase. This enzyme is also called orotate reductase (NADH). This enzyme participates in pyrimidine metabolism. It has 2 cofactors: FAD, and FMN.

References

• FRIEDMANN HC, VENNESLAND B (1958). "Purification and properties of dihydro-orotic dehydrogenase". J. Biol. Chem. 233 (6): 1398–406. PMID 13610849. 
• FRIEDMANN HC, VENNESLAND B (1960). "Crystalline dihydroorotic dehydrogenase". J. Biol. Chem. 235: 1526–32. PMID 13825167. 
• LIEBERMAN I, KORNBERG A (1953). "Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I Dihydro-orotic dehydrogenase". Biochim. Biophys. Acta. 12 (1–2): 223–34. doi:10.1016/0006-3002(53)90141-3. PMID 13115431. 

This EC 1.3 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 1.3.1 NADH-dependent enzymes Flavin enzymes Enzymes of unknown structure EC 1.3 stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу MAS 500 Texan sloop-of-war Austin Look at other dictionaries: List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia Dihydroorotate dehydrogenase — Dihydroorotate oxidase Identifiers EC number 1.3.3.1 CAS number 9029 03 2 …   Wikipedia List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”