- Demethylmacrocin O-methyltransferase
-
demethylmacrocin O-methyltransferase Identifiers EC number 2.1.1.102 CAS number 120313-64-6 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a demethylmacrocin O-methyltransferase (EC 2.1.1.102) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + demethylmacrocin
S-adenosyl-L-homocysteine + macrocin
Thus, the two substrates of this enzyme are S-adenosyl methionine and demethylmacrocin, whereas its two products are S-adenosylhomocysteine and macrocin.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:demethylmacrocin 2"'-O-methyltransferase. This enzyme is also called demethylmacrocin methyltransferase. This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.
References
- Kreuzman AJ, Turner JR, Yeh WK (1988). "Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis Substrate specificity, enzyme inhibition, and kinetic mechanism". J. Biol. Chem. 263 (30): 15626–33. PMID 3170602.
This transferase article is a stub. You can help Wikipedia by expanding it. - S-adenosyl-L-methionine + demethylmacrocin
