Cycloartenol 24-C-methyltransferase

Cycloartenol 24-C-methyltransferase
cycloartenol 24-C-methyltransferase
Identifiers
EC number 2.1.1.142
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cycloartenol 24-C-methyltransferase (EC 2.1.1.142) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + cycloartenol \rightleftharpoons S-adenosyl-L-homocysteine + (24R)-24-methylcycloart-25-en-3beta-ol

Thus, the two substrates of this enzyme are S-adenosyl methionine and cycloartenol, whereas its two products are S-adenosylhomocysteine and (24R)-24-methylcycloart-25-en-3beta-ol.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase. This enzyme is also called sterol C-methyltransferase.

References

  • Mangla AT, Nes WD (2000). "Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition". Bioorg. Med. Chem. 8 (5): 925–36. doi:10.1016/S0968-0896(00)00040-7. PMID 10882005.