- 3-oxoacyl-(acyl-carrier-protein) reductase
enzymology, a 3-oxoacyl- [acyl-carrier-protein] reductase (EC number|220.127.116.11) is an enzymethat catalyzes the chemical reaction
:(3R)-3-hydroxyacyl- [acyl-carrier-protein] + NADP+ 3-oxoacyl- [acyl-carrier-protein] + NADPH + H+
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl- [acyl-carrier-protein] :NADP+ oxidoreductase. Other names in common use include beta-ketoacyl- [acyl-carrier protein] (ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, NADPH-specific 3-oxoacyl- [acylcarrier protein] reductase, and 3-oxoacyl- [ACP] reductase. This enzyme participates in fatty acid biosynthesisand polyunsaturated fatty acidbiosynthesis.
As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1I01, PDB link|1O5I, PDB link|1Q7B, PDB link|1Q7C, PDB link|1ULS, PDB link|1UZL, PDB link|1UZM, PDB link|1UZN, PDB link|2A4K, PDB link|2B4Q, PDB link|2C07, PDB link|2FR0, PDB link|2FR1, PDB link|2NM0, PDB link|2NTN, PDB link|2P68, PDB link|2PFF, PDB link|2PH3, PDB link|2PNF, PDB link|2UVD, and PDB link|2Z5L.
CAS registry numberfor this enzyme class is CAS registry|37250-34-3."
Gene Ontology (GO) codes
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