5-amino-6-(5-phosphoribosylamino)uracil reductase

In enzymology, a 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC number|1.1.1.193) is an enzyme that catalyzes the chemical reaction

:5-amino-6-(5-phosphoribitylamino)uracil + NADP⁺ $ightleftharpoons$ 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H⁺

Thus, the two substrates of this enzyme are 5-amino-6-(5-phosphoribitylamino)uracil and NADP⁺, whereas its 3 products are 5-amino-6-(5-phosphoribosylamino)uracil, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2AZN, PDB link|2B3Z, PDB link|2D5N, PDB link|2G6V, PDB link|2HXV, PDB link|2O7P, and PDB link|2OBC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|69020-28-6."

Gene Ontology (GO) codes