Diaminohydroxyphosphoribosylaminopyrimidine deaminase

Diaminohydroxyphosphoribosylaminopyrimidine deaminase
diaminohydroxyphosphoribosylaminopyrimidine deaminase
Identifiers
EC number 3.5.4.26
CAS number 68994-19-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) is an enzyme that catalyzes the chemical reaction

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O \rightleftharpoons 5-amino-6-(5-phosphoribosylamino)uracil + NH3

Thus, the two substrates of this enzyme are 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and H2O, whereas its two products are 5-amino-6-(5-phosphoribosylamino)uracil and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds (specifically in cyclic amidines). The systematic name of this enzyme class is 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2B3Z, 2D5N, 2G6V, 2HXV, 2O7P, and 2OBC.

References