Ureidoglycolate dehydrogenase

In enzymology, an ureidoglycolate dehydrogenase (EC number|1.1.1.154) is an enzyme that catalyzes the chemical reaction

:(S)-ureidoglycolate + NAD(P)+ $ightleftharpoons$ oxalureate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD⁺, and NADP⁺, whereas its 4 products are oxalureate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)+ oxidoreductase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WTJ and PDB link|1XRH.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|62213-62-1."

Gene Ontology (GO) codes