N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Identifiers
EC number	3.1.4.45
CAS number	75788-84-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) is an enzyme that catalyzes the chemical reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H₂O $\rightleftharpoons$ N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Thus, the two substrates of this enzyme are glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose and H₂O, whereas its two products are N-acetyl-D-glucosamine and glycoprotein phospho-D-mannose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase. Other names in common use include alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, phosphodiester glycosidase, alpha-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester, and acetamidodeoxyglucohydrolase.

References

• Probst C, Grotz M, Krettek C, Pape HC (2005). "Impact of hypothermia on the immunologic response after trauma and elective surgery". Surg. Technol. Int. 14: 41–50. PMID 16525953. 
• van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145 (2): 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID 4399430. 
• Van der Drift L, Vogels GD, Van der Drift C (1975). "Allantoin racemase: a new enzyme from Pseudomonas species". Biochim. Biophys. Acta. 391 (1): 240–8. PMID 237557. 
• Waheed A, Hasilik A, von Figura K (1981). "Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase". J. Biol. Chem. 256 (11): 5717–21. PMID 6263889. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.1.4 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР N-acetylgalactosaminoglycan deacetylase Lipetsky Look at other dictionaries: NAGPA — N acetylglucosamine 1 phosphodiester alpha N acetylglucosaminidase Identifiers Symbols NAGPA; APAA; UCE External IDs …   Wikipedia List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”