Phosphogluconate 2-dehydrogenase
- Phosphogluconate 2-dehydrogenase
In enzymology, a phosphogluconate 2-dehydrogenase (EC number|1.1.1.43) is an enzyme that catalyzes the chemical reaction
:6-phospho-D-gluconate + NAD(P)+ 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+
The 3 substrates of this enzyme are 6-phospho-D-gluconic acid, NAD+, and NADP+, whereas its 4 products are 6-phospho-2-dehydro-D-gluconic acid, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase. Other names in common use include 6-phosphogluconic dehydrogenase, phosphogluconate dehydrogenase, gluconate 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD+), and 2-keto-6-phosphogluconate reductase. This enzyme participates in pentose phosphate pathway and glutathione metabolism.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9001-82-5."
Gene Ontology (GO) codes
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