Oxaloglycolate reductase (decarboxylating)

Oxaloglycolate reductase (decarboxylating)
oxaloglycolate reductase (decarboxylating)
Identifiers
EC number 1.1.1.92
CAS number 37250-28-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an oxaloglycolate reductase (decarboxylating) (EC 1.1.1.92) is an enzyme that catalyzes the chemical reaction

D-glycerate + NAD(P)+ + CO2 \rightleftharpoons 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H+

The 4 substrates of this enzyme are D-glycerate, NAD+, NADP+, and CO2, whereas its 4 products are 2-hydroxy-3-oxosuccinate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glycerate:NAD(P)+ oxidoreductase (carboxylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

  • Kohn LD, Jakoby WB (1968). "Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase". J. Biol. Chem. 243 (10): 2486–93. PMID 4385076.