Methylglyoxal reductase (NADH-dependent)

Methylglyoxal reductase (NADH-dependent)
methylglyoxal reductase (NADH-dependent)
Identifiers
EC number 1.1.1.78
CAS number 37250-16-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methylglyoxal reductase (NADH-dependent) (EC 1.1.1.78) is an enzyme that catalyzes the chemical reaction

(R)-lactaldehyde + NAD+ \rightleftharpoons methylglyoxal + NADH + H+

Thus, the two substrates of this enzyme are (R)-lactaldehyde and NAD+, whereas its 3 products are methylglyoxal, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include methylglyoxal reductase, and D-lactaldehyde dehydrogenase. This enzyme participates in pyruvate metabolism.

References

  • TING SM, MILLER ON, SELLINGER OZ (1965). "THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER". Biochim. Biophys. Acta. 97: 407–15. PMID 14323585. 
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