Glucose 1-dehydrogenase

In enzymology, a glucose 1-dehydrogenase (EC number|1.1.1.47) is an enzyme that catalyzes the chemical reaction

:beta-D-glucose + NAD(P)+ $ightleftharpoons$ D-glucono-1,5-lactone + NAD(P)H + H⁺

The 3 substrates of this enzyme are beta-D-glucose, NAD⁺, and NADP⁺, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Other names in common use include D-glucose dehydrogenase (NAD(P)+), and hexose phosphate dehydrogenase. This enzyme participates in pentose phosphate pathway.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1G6K, PDB link|1GCO, PDB link|1GEE, PDB link|1RWB, PDB link|1SPX, PDB link|2B5V, PDB link|2B5W, PDB link|2CD9, and PDB link|2CDA.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-53-9."

Gene Ontology (GO) codes