UDP-glucose 6-dehydrogenase
- UDP-glucose 6-dehydrogenase
In enzymology, an UDP-glucose 6-dehydrogenase (EC number|1.1.1.22) is an enzyme that catalyzes the chemical reaction
:UDP-glucose + 2 NAD+ + H2O UDP-glucuronate + 2 NADH + 2 H+
The 3 substrates of this enzyme are UDP-glucose, NAD+, and H2O, whereas its 3 products are UDP-glucuronate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD+ 6-oxidoreductase. Other names in common use include UDP-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, UDPG dehydrogenase, UDPG:NAD oxidoreductase, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-glucose:NAD+ oxidoreductase, uridine diphosphate glucose dehydrogenase, UDP-D-glucose dehydrogenase, and uridine diphosphate D-glucose dehydrogenase. This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.
tructural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DLI, PDB link|1DLJ, PDB link|2O3J, PDB link|2Q3E, and PDB link|2QG4.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9028-26-6."
Gene Ontology (GO) codes
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2010.
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UDP-Glucose-6-Dehydrogenase — Vorhandene Strukturdaten: s. UniProt Masse/Länge … Deutsch Wikipedia
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metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism … Universalium
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