UGDH

UDP-glucose dehydrogenase, also known as UGDH, is a human gene.cite web | title = Entrez Gene: UGDH UDP-glucose dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7358| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.cite web | title = Entrez Gene: UGDH UDP-glucose dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7358| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Spicer AP, Kaback LA, Smith TJ, Seldin MF |title=Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25117–24 |year= 1998 |pmid= 9737970 |doi=
*cite journal | author=Peng HL, Lou MD, Chang ML, Chang HY |title=cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. |journal=Proc. Natl. Sci. Counc. Repub. China B |volume=22 |issue= 4 |pages= 166–72 |year= 1999 |pmid= 9850599 |doi=
*cite journal | author=Marcu O, Stathakis DG, Marsh JL |title=Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3-4 |pages= 244–5 |year= 2000 |pmid= 10575217 |doi=
*cite journal | author=Bontemps Y, Maquart FX, Wegrowski Y |title=Human UDP-glucose dehydrogenase gene: complete cloning and transcription start mapping. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 3 |pages= 981–5 |year= 2000 |pmid= 10973831 |doi= 10.1006/bbrc.2000.3389
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bontemps Y, Vuillermoz B, Antonicelli F, "et al." |title=Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21566–75 |year= 2003 |pmid= 12682078 |doi= 10.1074/jbc.M209366200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sommer BJ, Barycki JJ, Simpson MA |title=Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23590–6 |year= 2004 |pmid= 15044486 |doi= 10.1074/jbc.M401928200
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Huh JW, Yoon HY, Lee HJ, "et al." |title=Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37491–8 |year= 2004 |pmid= 15247292 |doi= 10.1074/jbc.M404234200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huh JW, Lee HJ, Choi MM, "et al." |title=Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis. |journal=Bioconjug. Chem. |volume=16 |issue= 3 |pages= 710–6 |year= 2005 |pmid= 15898741 |doi= 10.1021/bc0500387
*cite journal | author=Vatsyayan J, Peng HL, Chang HY |title=Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript. |journal=J. Biochem. |volume=137 |issue= 6 |pages= 703–9 |year= 2005 |pmid= 16002992 |doi= 10.1093/jb/mvi082
*cite journal | author=Wang L, Zhu YF, Guo XJ, "et al." |title=A two-dimensional electrophoresis reference map of human ovary. |journal=J. Mol. Med. |volume=83 |issue= 10 |pages= 812–21 |year= 2006 |pmid= 16021519 |doi= 10.1007/s00109-005-0676-y
*cite journal | author=Vatsyayan J, Lin CT, Peng HL, Chang HY |title=Identification of a cis-acting element responsible for negative regulation of the human UDP-glucose dehydrogenase gene expression. |journal=Biosci. Biotechnol. Biochem. |volume=70 |issue= 2 |pages= 401–10 |year= 2006 |pmid= 16495656 |doi=
*cite journal | author=Huh JW, Robinson RC, Lee HS, "et al." |title=Expression, purification, crystallization, and preliminary X-Ray analysis of the human UDP-glucose dehydrogenase. |journal=Protein Pept. Lett. |volume=13 |issue= 8 |pages= 859–62 |year= 2006 |pmid= 17073734 |doi=
*cite journal | author=Easley KE, Sommer BJ, Boanca G, "et al." |title=Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280. |journal=Biochemistry |volume=46 |issue= 2 |pages= 369–78 |year= 2007 |pmid= 17209547 |doi= 10.1021/bi061537d

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