SOD1

SOD1

Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)), also known as SOD1, is a human protein and gene. This gene encodes one of three forms of the human superoxide dismutase.

PBB_Summary
section_title =
summary_text = SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. [cite journal|last=Conwit|first=Robin A.|title=Preventing familial ALS: A clinical trial may be feasible but is an efficacy trial warranted?|journal=Journal of the Neurological Sciences|year=2006|month=December|volume=251|issue=1–2|pages=1–2|doi=10.1016/j.jns.2006.07.009|issn=0022-510X] [cite journal|last=Al-Chalabi|first=Ammar|coauthor=P. Nigel Leigh|title=Recent advances in amyotrophic lateral sclerosis|journal=Current Opinion in Neurology|year=2000|month=August|volume=13|issue=4|pages=397–405|doi=|issn=1473-6551] Rare transcript variants have been reported for this gene. [cite web | title = Entrez Gene: SOD1 superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6647| accessdate = ]

Mice lacking Sod1 have increased age-related muscle mass loss, early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortned lifespan.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=de Belleroche J, Orrell R, King A |title=Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developments. |journal=J. Med. Genet. |volume=32 |issue= 11 |pages= 841–7 |year= 1996 |pmid= 8592323 |doi=
*cite journal | author=Ceroni M, Curti D, Alimonti D |title=Amyotrophic lateral sclerosis and SOD1 gene: an overview. |journal=Funct. Neurol. |volume=16 |issue= 4 Suppl |pages= 171–80 |year= 2002 |pmid= 11996514 |doi=
*cite journal | author=Zelko IN, Mariani TJ, Folz RJ |title=Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. |journal=Free Radic. Biol. Med. |volume=33 |issue= 3 |pages= 337–49 |year= 2003 |pmid= 12126755 |doi=
*cite journal | author=Hadano S |title= [Causative genes for familial amyotrophic lateral sclerosis] |journal=Seikagaku |volume=74 |issue= 6 |pages= 483–9 |year= 2002 |pmid= 12138710 |doi=
*cite journal | author=Noor R, Mittal S, Iqbal J |title=Superoxide dismutase--applications and relevance to human diseases. |journal=Med. Sci. Monit. |volume=8 |issue= 9 |pages= RA210–5 |year= 2003 |pmid= 12218958 |doi=
*cite journal | author=Potter SZ, Valentine JS |title=The perplexing role of copper-zinc superoxide dismutase in amyotrophic lateral sclerosis (Lou Gehrig's disease). |journal=J. Biol. Inorg. Chem. |volume=8 |issue= 4 |pages= 373–80 |year= 2004 |pmid= 12644909 |doi= 10.1007/s00775-003-0447-6
*cite journal | author=Rotilio G, Aquilano K, Ciriolo MR |title=Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes. |journal=IUBMB Life |volume=55 |issue= 10-11 |pages= 629–34 |year= 2004 |pmid= 14711010 |doi=
*cite journal | author=Jafari-Schluep HF, Khoris J, Mayeux-Portas V, "et al." |title= [Superoxyde dismutase 1 gene abnormalities in familial amyotrophic lateral sclerosis: phenotype/genotype correlations. The French experience and review of the literature] |journal=Rev. Neurol. (Paris) |volume=160 |issue= 1 |pages= 44–50 |year= 2004 |pmid= 14978393 |doi=
*cite journal | author=Faraci FM, Didion SP |title=Vascular protection: superoxide dismutase isoforms in the vessel wall. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1367–73 |year= 2005 |pmid= 15166009 |doi= 10.1161/01.ATV.0000133604.20182.cf

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • SOD1 — [[Изображение:|px|Супероксиддисмутаза 1 chemical structure]] супероксиддисмутаза 1, цитозольная Обозначения Symbol(s) SOD1 ALS, ALS1 Entrez …   Википедия

  • sod — sod1 sodless, adj. /sod/, n., v., sodded, sodding. n. 1. a section cut or torn from the surface of grassland, containing the matted roots of grass. 2. the surface of the ground, esp. when covered with grass; turf; sward. v.t. 3. to cover with… …   Universalium

  • sod — sod1 [sɔd US sa:d] n [Date: 1400 1500; : Middle Dutch; Origin: Middle Low German sode] 1.) BrE informal not polite a very offensive word for someone, especially a man, who you think is stupid or annoying ▪ Get up, you lazy sod! 2.) be a sod BrE… …   Dictionary of contemporary English

  • sod — sod1 noun turf. ↘a piece of turf. verb (sods, sodding, sodded) rare cover with turf or pieces of turf. Phrases under the sod dead and buried. Origin ME: from MDu., Mid. Low Ger. sode, of unknown ultimate origin. sod2 vulgar slang …   English new terms dictionary

  • Amyotrophic lateral sclerosis — This article is about progressive Motor Neuron Disease (MND) affecting both the upper motor neurons and lower motor neurons. For MND affecting either but not necessarily both, see Motor neurone disease. ALS redirects here. For other uses, see ALS …   Wikipedia

  • Superoxide dismutase — For other senses of the term SOD/Sod, see Sod (disambiguation). Superoxide dismutase Structure of a human Mn superoxide dismutase 2 tetramer.[1] …   Wikipedia

  • Superóxido dismutasa — Estructura de la unidad monomérica de superóxido dismutasa 2 humana. Superóxido dismutasa 1, soluble HUGO …   Wikipedia Español

  • Motor neurone disease — Classification and external resources spinal diagram ICD 10 G12.2 …   Wikipedia

  • Супероксиддисмутаза 1 — супероксиддисмутаза 1, цитозольная Обозначения Символы SOD1; ALS, ALS1 Entrez Gene …   Википедия

  • Progressive bulbar palsy — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD10|G|12|2|g|10 ICD9 = ICD9|335.22 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshName = Bulbar+Palsy,+Progressive MeshNumber = C10.574.562.300 Progressive Bulbar… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”