- Downregulated-in-adenoma
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The downregulated-in-adenoma (DRA) is a membrane protein in intestinal cells. It is an anion exchanger and a member (SLC26A3) of the sulfate anion transporter (SAT) family. It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part of the plasma membrane of enterocytes. The congenital absence of this membrane protein results in an autosomal recessive disorder called congenital chloridorrhea or congenital chloride diarrhea (CLD). It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues.
External links
- Sterling, D., et al. (2002). The functional and physical relationship between the downregulated in adenoma bicarbonate transporter and carbonic anhydrase II. Am J Physiol.
- Alrefai WA, et al. (2007) Molecular cloning and promoter analysis of downregulated in adenoma (DRA) Am J Physiol.
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