Pelger-Huet anomaly

Pelger-Huet anomaly

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB = 29515
ICD10 = ICD10|D|72|0|d|70
ICD9 = ICD9|288.2
ICDO =
OMIM = 169400
MedlinePlus =
eMedicineSubj = ped
eMedicineTopic = 1753
MeshID = D010381

Pelger-Huet anomaly is a blood laminopathy associated with the lamin B receptor. It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.

It is a genetic disorder with an autosomal dominant inheritance pattern. Heterozygotes are clinical normal although their neutrophils may be mistaken for immature cells which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.


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