Trans-endocytosis

Trans-endocytosis

Trans-endocytosis is the biological process where material created in one cell undergoes endocytosis (enters) into another cell. If the material is large enough, this can be observed using an electron microscope. [cite journal
author=Spacek J
coauthors=Harris K.
year=2004
month=Apr
title=Trans-endocytosis via spinules in adult rat hippocampus
journal=J Neurosci.
volume=24
issue=17
pages=4233–4241
pmid=15115819
doi=10.1523/JNEUROSCI.0287-04.2004] Trans-endocytosis from neurons to glia has been observed using time-lapse microscopy. [cite journal
author=Lauterbach J
coauthors=Klein R.
year=2006
month=Nov
title=Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells
journal=J Neurosci.
volume=26
issue=45
pages=11575–11581
pmid=17093078
doi=10.1523/JNEUROSCI.2697-06.2006]

Trans-endocytosis also applies to molecules. For example, this process is involved when a part of the protein Notch is cleaved off and undergoes endocytosis into its neighboring cell. [cite journal
author=Krämer H.
title=RIPping notch apart: a new role for endocytosis in signal transduction?
journal=Sci STKE.
year=2000
month=Apr
volume=2000
issue=29
pages=pe1
pmid=11752592] [cite journal
author=Parks AL
coauthors=Klueg KM, Stout JR, Muskavitch MA.
year=2000
month=Apr
title=Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
journal=Development
volume=127
issue=7
pages=1373–1385
pmid=10704384] Without Notch trans-endocytosis, there would be too many neurons in a developing embryo. [cite journal
author=Klueg KM
coauthors=Muskavitch MA.
year=1999
month=Oct
title=Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila
journal=J Cell Sci.
volume=112
issue=19
pages=3289–3297
pmid=10504334] Trans-endocytosis is also involved in cell movement when the protein ephrin is bound by its receptor from a neighboring cell. [cite journal
author=Marston DJ
coauthors=Dickinson S, Nobes CD.
year=2003
month=Oct
title=Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
journal=Nat Cell Biol.
volume=5
issue=
pages=879–888
pmid=12973357
doi=10.1038/ncb1044]

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