Richter's transformation

Richter's transformation

Richter's transformation, or Richter's syndrome (RS) is a rare complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL). With Ricther's, CLL changes into a fast-growing diffuse large B cell lymphoma. [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=523286] It affects perhaps 2% to 8% of CLL patients at some point during their lives.

ymptoms

Symptoms of Richter’s transformation include fever, loss of weight and muscle mass, and enlarged lymph nodes. [http://cllfaq.acor.org/answers/58.html] Richter's can appear suddenly, even in patients who were in remission. The prognosis is generally poor, and aggressive treatment is usually warranted.

External links

* [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=489396 Richter syndrome] entry in the public domain NCI Dictionary of Cancer Terms


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