Optochin

Optochin
Optochin
IUPAC name
(4β,8α,9R)-6'-Ethoxy-10,11-dihydrocinchonan-9-ol
Other names
Ethylhydrocupreine
Identifiers
CAS number 522-60-1 YesY
PubChem 71542
MeSH Optochin
Properties
Molecular formula C21H28N2O2
Molar mass 340.46 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Optochin (or ethylhydrocupreine) is a chemical used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as Streptococcus viridans which are resistant. A common mnemonic is "OVRPS" (Optochin - Viridans Resistant, Pneumoniae Sensitive).

The growth of Bacteria that are optochin sensitive will be inhibited around an optochin disc, while the growth of bacteria that are optochin resistant will not be affected. In vitro a solution of as little as 1: 10,000,000 may be inhibitory to the pneumococcus, and 1: 500,000 is bactericidal.[1]

Resistance

Strains of Streptococcus pneumoniae have been found to be resistant to optochin in laboratory testing.[2]

References

  1. ^ http://chestofbooks.com/health/materia-medica-drugs/Pharmacology-Therapeutics-Prescription-Writing/Ethylhydrocupreine.html
  2. ^ Pikis A, Campos JM, Rodriguez WJ, Keith JM (2001), "Optochin resistance in Streptococcus pneumoniae: mechanism, significance, and clinical implications", Journal of Infectious Diseases 184 (5): 582–590, doi:10.1086/322803, PMID 11474432, http://www.journals.uchicago.edu/doi/pdf/10.1086/322803?cookieSet=1 

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