History of electroconvulsive therapy in the United Kingdom

Electroconvulsive therapy (ECT, in the past sometimes called electric convulsion therapy or electroplexy) is a controversial psychiatric treatment in which seizures are induced with electricity.Carney S and Geddes J (2003) Editorial: electroconvulsive therapy. "British Medical Journal" 326: 1343-4.] ECT was first used in the United Kingdom in 1939 and, although its use has been declining for several decades, it is still given to about 11,000 people a year.Electroconvulsive therapy: survey covering the period from January 2002 to March 2002, "Statistical Bulletin 2003/08". Department of Health.]

In contemporary psychiatric practice ECT is used mainly in the treatment of depression. It is occasionally used in the treatment of other disorders such as schizophrenia. When undergoing modern ECT, a patient is given an anaesthetic and a muscle relaxant. An brief-pulse electric current of about 800 milliamps is passed between two electrodes on the head for several seconds causing a seizure. [Lock T (1995) Appendix VI: review of ECT machines. In C Freeman (ed) "The ECT Handbook". London: Royal College of Psychiatrists.] The resulting convulsion is modified by the muscle relaxant. ECT is usually given on an inpatient basis; about one in five treatments are given on an outpatient basis. Treatment is usually given twice a week (occasionally three times a week) for a total of 6-12 treatments, although courses may be longer or shorter.About 70 per cent of ECT patients are women. Over 2,000 ECT patients a year are treated without their consent under the Mental Health Act 1983 or the provisions of common law. [The Mental Health Act Commission (2003) "Tenth biennial report, 2001-2003", 152.]

Early years: 1937-1969

ECT was invented in Italy in 1937. Two years later it was brought to England and replaced cardiazol (metrazol) as the preferred method of inducing seizures in convulsion therapy in British mental hospitals. Although soon established as especially useful in the treatment of depression, it was also used on people with a wide variety of mental disorders. There was large variation in the amount of ECT used between different hospitals. As well as being used therapeutically, ECT was used to control the behaviour of patients. Originally given in unmodified form (without anaesthetics and muscle relaxants) hospitals gradually switched to using modified ECT, a process that was accelerated by a famous legal case.

Origins of ECT

Convulsive therapy was introduced in 1934 by Hungarian neuropsychiatrist Ladislas J Meduna who, believing that schizophrenia and epilepsy were antagonistic disorders, induced seizures in patients with first camphor and then cardiazol. [Mowbray RM (1959) Historical aspects of electric convulsant therapy. "Scottish Medical Journal" 4: 373-378.]

Meanwhile in Rome, professor of neuropsychiatry Ugo Cerletti was doing research on epilepsy and using electric shocks to induce seizures in dogs.Cerletti U (1956) Electroshock therapy. In AM Sackler "et al". (eds) "The Great Physiodynamic Therapies in Psychiatry: an historical appraisal." New York: Hoeber-Harper, 91-120.] Cerletti visited the Rome abbatoir where electric shocks were used to render pigs comatose prior to slaughter. Inspired by the fact that the pigs were not actually killed by a current of 125 volts passed through the head for a few tenths of a second, he decided to experiment on a person. In April 1938 Cerletti tried ECT for the first time on a man who had been brought to his clinic in a confused state by police. The man was given a total of 11 treatments and recovered. It later emerged that he had had cardiazol treatment in another hospital three months previously. Cerletti called his treatment "electroshock" and developed a theory that it worked by causing the brain the produce vital substances that he called "acro-agonines" (from the Greek for "extreme struggle"). He put his theory into practice by injecting patients with a suspension of electroshocked pig brain, with encouraging results. Electroshocked pig brain therapy was used by a few psychiatrists in Italy, France and Brazil but did not become as popular as ECT. Cardiazol convulsion therapy was soon replaced by ECT all over the world. Cerletti and Bini were nominated for a Nobel prize but did not get one.

Early use of ECT in the UK

ECT arrived in the UK with Lothar Kalinowsky, one of Cerletti’s assistants, who was on his way to the USA. Kalinowsky demonstrated Cerletti’s technique at the Burden Neurological Institute (BNI) and wrote an article about ECT which appeared in the Lancet in December 1939. Kalinowsky L (1939) Electric convulsion therapy in schizophrenia. "Lancet" 234, 9 December: 1232-33.] He said that electrically induced seizures were cheaper and easier to administer than cardiazol seizures. The first paper on ECT by British authors appeared three weeks later in the same journal.Fleming GWTH, Golla FL and Grey Walter W (1939) Electric convulsion therapy of schizophrenia. "Lancet" 234, 30 December: 1352-1355.] Gerald Fleming, the medical superintendent of Barnwood House Hospital in Gloucester and editor of the Journal of Mental Science, psychiatrist Frederic Golla and neurophysiologist William Grey Walter (both from the BNI) described how they had tested the new method of convulsion therapy on five chronic schizophrenic patients from Barnwood House. Electrical parameters, technique of administration, seizures and electroencephalograms, but not therapeutic results, were discussed. An accompanying editorial entitled "More shocks" said that ECT "may well turn out to be a valuable step forward" but criticised Fleming’s claim that the use of ECT required only minimal training, expertise and patient preparation. The editorial also queried Kalinowsky’s dismissal of concerns about brain damage. "There is still a chance" it said "that the brain has nemo me impune lacessit for its motto." [Editorial (1939) More shocks. "Lancet" 234, 30 December: 1373.]

ECT soon became more popular than cardiazol convulsion therapy in mental hospitals in the UK. [Mccrae N (2006)'A violent thunderstorm': cardiazol treatment in British mental hospitals. "History of Psychiatry" 17: 67-90.] It was quickly identified as being especially useful in the treatment of affective psychosis. Brain WR and Strauss EB (1945) "Recent advances in neurology and neuropsychiatry", 5th edition. London: J & A Churchill Ltd.] The therapeutic value of ECT in schizophrenia was recognised as limited, but some psychiatrists saw it as useful to control the behaviour of institutionalised patients who had been diagnosed as schizophrenic. Some psychiatrists thought that ECT should be restricted to the treatment of depression;Allen C (1949) "Modern discoveries in medical psychology", 2nd edition. London: MacMillan and Co Ltd.] others used it in the treatment of a wide variety of disorders, for example, schizophrenia, epilepsy, neurosis, and hysteria.Hemphill RE and Grey Walter W (1941) The treatment of mental disorders by electrically induced convulsions. "Journal of Mental Science" 87: 257-275.] It was also used on people who had suffered war trauma. [Sargant W (1942) Physical treatment of acute war neurosis: some clinical observations. "British Medical Journal", 14 November: 574-576.] By the mid 1950s there was a 20 fold difference in the rate of ECT use in mental hospitals in the UK, and a similar difference in its rate of use in teaching hospitals.Barker JC and Baker AA (1959) Deaths associated with electroplexy. "Journal of Mental Science" 105: 339-348.] In the 1940s and 1950s ECT machines used sine-wave current and patients were given a shock lasting a fraction of a second.

Views on ECT were generally positive in the early days of its use. The Ministry of Labour ran a recruitment campaign for psychiatric nurses featuring a picture of someone undergoing ECT. ["Times", February 20 1947, p7.] Barnwood House, which catered for "ladies and gentlemen suffering from nervous and mental disorders", said in advertisements that it offered "all the most modern methods of treatment including electric shock and prefrontal leucotomy". [Advertisement for Barnwood House. "Journal of Mental Science", January 1948, page vii.] There were however dissenting voices. Cyril Birnie, the medical superintendent of St Bernard’s Hospital, Middlesex, raised concerns about persistent intellectual deficits following treatment and said that mental patients were "in danger of having a pretty thin time of it". [Golla FL (1940) Electrically induced convulsions. "Lancet" 235, January 20: 127-128.]

Anaesthesia

In the 1940s and early 1950s ECT was usually given in unmodified form, that is, without muscle relaxants, and the seizure resulted in a full-scale convulsion. An anaesthetic was used by a few psychiatrists but most considered it unnecessary as the electric shock produced instant unconsciousness.Kiloh LG, Smith JS, Johnson GF (1988). "Physical Treatments in Psychiatry". Melbourne: Blackwell Scientific Publications, 190-208. ISBN 0-86793-112-4] ECT was even occasionally used to anaesthetise patients for psychosurgical operations. [Freeman W (1948) Transorbital leucotomy. "Lancet" 252, 4 September: 371-37.]

A rare but serious complication of unmodified ECT was fracture or dislocation of the long bones, caused by the violence of the muscular contractions during the convulsion. In the 1940s psychiatrists began to experiment with curare, the muscle-paralysing South American poison, in order to modify the convulsions. The introduction in 1951 of succinylcholine, a safer synthetic alternative to curare, led to the more widespread use of modified ECT. A short-acting anaesthetic was usually given in addition to the muscle relaxant in order to spare patients the terrifying feeling of suffocation that can be experienced with muscle relaxants. By the mid 1950s most hospitals in Britain routinely used modified ECT, although a few still used unmodified ECT or ECT with muscle relaxants but without anaesthetic. In 1957 a patient who had sustained fractures to both hips whilst undergoing unmodified ECT at a London hospital took legal action. He lost the case but it had far-reaching consequences, encouraging a debate about ECT techniques which led to the abandonment of routine use of unmodified ECT in British hospitals. [Barker JC (1958). Electroplexy (ECT) techniques in current use. "Journal of Mental Science" 104: 1069-78.] The case is also famous for having established the Bolam principle.

Intensive ECT

Most patients in the early years of ECT were given treatment two or three times a week, or occasionally daily; a few psychiatrists experimented with more intensive treatment. At St James Hospital, Portsmouth, William Liddell Milligan gave neurotic patients ECT up to four times daily. His aim was "to reduce the patient to the infantile level, in which he is completely helpless and doubly incontinent". [Liddell Morgan W (1946) Psychoneuroses treated with electrical convulsions: the intensive method. "Lancet" 248, 2 November: 653.] Robert Russell and Lewis Page tried a slightly different regime, giving patients one or two sessions of ECT a day but with several additional electric shocks during the convulsion. This treatment was given to over 3,800 patients at the Three Counties Hospital. Arlesey, Bedfordshire. [Russell RJ, Page LGM and Jillett RL (1953) Intensified electroconvulsant therapy: review of five years’ experience. "Lancet" 262, 5 December: 1177-1179.] The Page-Russell technique was taken up by Scottish-American psychiatrist D Ewen Cameron who used it to "depattern" his patients at the McGill University in Canada. [Cameron DE (1962) The depatterning treatment of schizophrenia. "Comprehensive Psychiatry" 3: 65-76.] It later emerged that the CIA had put funds into Professor Cameron’s work. In 1988 nine of his former patients received compensation from the US government; the Canadian government later compensated those patients whose treatment had not been funded by the CIA and court cases continue to this day. [Canada to pay victims of mind-altering treatment. "New York Times", 19 November 1992.] [Brainwash victims win cash claims. "Sunday Times – Scotland", 17 October 2004.]

Robert Russell set up a company, Ectron Ltd, to manufacture ECT machines. [Russell RJ (1988) Stimuli used in ECT. In JC Malkin and S Brandon (eds) "Current Approaches: ECT". Southampton: Duphar Medical Relations, 58-60.] At one time nearly every hospital in the UK was equipped with Ectron machines. Pippard J (1992) Audit of electroconvulsive treatment in two National Health Service regions. "British Journal of Psychiatry" 160: 621-37.]

The middle years: 1960–1985

The next two and a half decades saw ECT maintain its place as a commonly used psychiatric treatment in spite of the introduction of neuroleptics, antidepressants and benzodiazipines into British psychiatric practice in the late 1950s and early 1960s. In the early 1970s there were an estimated 50,000 courses annually in the UK; by 1985 this had dropped to about 24,000. This period saw stirrings of professional and public disquiet over some aspects of ECT use; in response the Royal College of Psychiatrists produced guidelines and carried out an extensive survey of ECT use. The Mental Health Act of 1983 introduced a legal framework for the use of ECT on non-consenting patients.

Guidelines

In 1976 the Royal College of Psychiatrists received a request from the regional medical officer of the South East Thames regional health authority for advice on giving ECT to non-consenting patients. One of the region’s mental hospitals had been the subject of a committee of enquiry, and the use of force when giving patients ECT had been criticised. [Inquiry upholds complaints of grossly bad care for mental hospital’s patients. "Times", 31 March 1976.] In Parliament, Secretary of State David Ennals had referred to the death of one woman following ECT as "disturbing". [ "Commons Hansard", 25 May 1976, oral answers, column 254.]

The Royal College of Psychiatrists duly produced guidelines, in the form of an eleven-page article in the British Journal of Psychiatry.Royal College of Psychiatrists (1977) Memorandum on the use of electroconvulsive therapy. "British Journal of Psychiatry" 131: 261-272] The guidelines summarised the current state of knowledge about ECT, set standards for its administration and discussed aspects of consent. ECT was, the guidelines concluded, an effective treatment for endogenous depression. There was less certainty about its value in mania, and little evidence for its usefulness in schizophrenia. The guidelines said that the possibility of long-term memory impairment following ECT had been "too little investigated". Recommendations for the administration of ECT included: anaesthesia for all patients, a pre-treatment physical examination, avoidance of currents greatly above seizure threshold and the use of machines with a choice of waveforms. The question of electrode placement was left open: evidence of less memory loss with unilateral electrode placement was noted, so too was psychiatrists’ preference for bilateral electrode placement. The guidelines recommended that informal patients who were unable or unwilling to consent to ECT should be sectioned and a second opinion obtained (unless the need for treatment was seen as urgent).

urvey

In 1981 the Royal College of Psychiatrists published the results of an extensive survey into the use of ECT in Great Britain.Pippard J and Ellam L (1981). "Electroconvulsive treatment in Great Britain, 1980". London: Gaskell.] It revealed many psychiatrists ignoring the guidelines. “ECT in Britain: a shameful state of affairs” read the title of a Lancet editorial on the results of the survey.Editorial (1981) ECT in Britain: a shameful state of affairs. "Lancet" 318: 1207-1208.] Less than half of the clinics visited by the researchers met the minimum standards in the guidelines. In many clinics, ECT was being given by "bored and uninterested staff with obsolete machines operated by ignorant and uncaring psychiatrists". One clinic, where the staff used the phrase "old is gold" was using a 30 year old machine mended with sticking plaster.

A total of about 27,000 people received ECT in 1980. The authors of the survey estimated that ECT use had approximately halved since the early 1970s. There was wide regional variation, with the heaviest user, Jersey and Guernsey, using ECT at more than 5 times the rate of the lowest user, the Oxford region. There was a 17 fold difference in rates of ECT use between different hospitals and in many hospitals a large proportion of ECT was given by just one or two psychiatrists. Some psychiatrists didn’t use ECT at all; others thought that the main, or even the only, indication for ECT was in psychotic or endogenous depression; yet others thought it appropriate in the treatment of a wide range of disorders. The median age of patients was mid-fifties. About 900 people over 80, and about 420 people under 20, were given ECT in 1980. 69 per cent were women. 21 per cent were treated with unilateral ECT.

The survey found that a small number of clinics were still, in 1980, occasionally using unmodified ECT. That same year it emerged that ECT without anaesthetic had been used to control a patient's behaviour in Broadmoor Hospital; such use was defended by the Royal College of Psychiatrists and the Department of Health. ["Commons Hansard", 26 January 1981, col 744-750.]

Legislation

The Mental Health Act 1959 had given psychiatrists implied authority to treat detained patients without consent. The Mental Health Act 1983 gave psychiatrists explicit authority to treat detained patients without consent.Jones, R (1996) Mental Health Act Manual, 5th edition. London: Sweet and Maxwell.]

Psychosurgery and the surgical implantation of hormones to reduce male sexual drive were classified as irreversible treatments that could only be carried out on consenting patients (section 57 of part IV of the Act); ECT was classified as a slightly less serious treatment that could be given to non-consenting patients if certain procedures were followed (section 58). The patient had to be detained (if they were not already detained), then a psychiatrist from the Mental Health Act Commission had to authorise treatment. If the treating psychiatrist decided there was an urgent need for ECT it could go ahead without authorisation from a Mental Health Act Commission psychiatrist (section 62).

ECT was not actually put on the face of the Bill, in recognition of the fact that some people thought it belonged in section 57 with irreversible treatments and a subsequent Secretary of State might wish to move it there. ["Commons Hansard", 18 October 1982, col 86.]

The Mental Health Act 1983 covers England and Wales. The Mental Health (Scotland) Act 1984 and the Mental Health (Northern Ireland) Order 1986 made similar provisions for the use of ECT on non-consenting patients in Scotland and Northern Ireland.

Recent years: 1986-2007

The use of ECT in the UK has continued to fall, from about 23,000 courses in 1986 to about 11,000 in 2002. There is still marked variation in use, both in prescribing and in standards of administration. The Royal College of Psychiatrists produced three more sets of guidelines, and carried out two more surveys. The National Health Service produced guidelines on ECT use in 2003 and the following year the Royal College of Psychiatrists set up a voluntary accreditation scheme for ECT clinics.

More guidelines and surveys

The Royal College of Psychiatrists produced another set of guidelines in 1989, followed by a survey which showed that, although there had been improvements since the previous survey in 1980, many hospitals still failed to meet the standards set out in the guidelines. This time the survey was limited to East Anglia, and showed a 12 fold difference in the rate of ECT use between hospitals.Further guidelines appeared in 1995, followed by yet another survey with similar results. There were still problems with the training and supervision of doctors administering ECT; only a quarter of clinics were rated as good and two-thirds failed to meet the most recent standards.Duffett R and Lelliott P (1998) Auditing electroconvulsive therapy: the third cycle. "British Journal of Psychiatry" 172: 401-405.] In 2004 the Royal College of Psychiatrists set up a voluntary accreditation scheme for ECT clinics. Two years on, only a minority of clinics in England, Wales, Northern Ireland and the Republic of Ireland had signed up. [Royal College of Psychiatrists (2006). [http://www.rcpsych.ac.uk/crtu/centreforqualityimprovement/electroconvulsivetherapy.aspx "ECTAS newsletter"] , issue 5.]

In 2003 the National Institute for Clinical Excellence, a government body which was set up to standardize treatment throughout the National Health Service, issued guidance on the use of ECT. Its use was recommended "only to achieve rapid and short-term improvement of severe symptoms after an adequate trial of treatment options has proven ineffective and/or when the condition is considered to be potentially life-threatening in individuals with severe depressive illness, catatonia or a prolonged manic episode". [NICE (2003) [http://www.nice.org.uk/page.aspx?o=TA059guidance "Guidance on the use of electroconvulsive therapy"] . London: NICE.] The guidance got a mixed reception. It was welcomed by an editorial in the British Medical Journal, but the Royal College of Psychiatrists launched an unsuccessful appeal. [NICE (2003) [http://www.nice.org.uk/page.aspx?o=62452 "Appraisal of electroconvulsive therapy: decision of the appeal panel"] . London: NICE.]

Effectiveness and adverse effects

In 2003 the UK ECT Review Group, led by Professor Geddes of Oxford University, reviewed the evidence and concluded that ECT had been shown to be an effective short-term treatment for depression—as measured by symptom rating scales—in physically healthy adults, and that it was probably more effective than drug treatment. Bilateral ECT was more effective than unilateral, and high-dose was more effective than low-dose. Their conclusions were qualified: most of the trials were old and conducted on small numbers of patients; some groups (for example, elderly people, women with postpartum depression and people with treatment-resistant depression) were under-represented in the trials even though ECT is believed to be especially effective for them. [The UK ECT Review Group (2003)Efficacy and safety of electroconvulsive therapy in depressive disorders: a systemic review and meta-analysis. "Lancet" 361: 799-808.]

A review of the literature found that between 29 per cent and 55 per cent (depending on the study) of people who had undergone ECT reported persistent memory loss. [Rose, D "et al". (2003). Patients' perspectives on electroconvulsive therapy: systematic review. "British Medical Journal" 326: 1363-1365.]

Treatment without consent

Although the use of ECT on consenting patients fell by over a half between 1986 and 2002, its use on non-consenting patients remained constant at just over 2,000 people a year (in England and Wales). [The Mental Health Act Commission (2003) "Tenth biennial report, 2001-2003", 152.] About two-thirds of those treated without their consent lack capacity, the rest are "capable but refusing". [The Mental Health Act Commission (1999) "Eleventh biennial report, 2003-2005", 240.] As well as those treated under sections 58 and 62 of the Mental Health Act 1983, a small number of informal patients are treated without their consent under the common law. In 2002, just over one in five ECT patients had not consented to treatment.

In Scotland the Mental Health (Care and Treatment) (Scotland) Act 2003 gave patients with capacity the right to refuse ECT. [The Mental Health (Care and Treatment) (Scotland) Act 2003, Part 16, sections 237-239.]

Parliament in London is currently considering amendments to the Mental Health Act 1983, including one which would give capable people the right to refuse ECT in some circumstances. [See for example, "Lords Hansard", 15 January 2007; "Commons Hansard", 18 June 2007.]

Notes