VA RNA

VA RNA

The VA (viral associated) RNA is a non-coding RNA found in adenovirus. [cite journal | last = Mathews | first = MB | year = 1995 | title = Structure, function, and evolution of adenovirus virus-associated RNAs | journal = Curr Top Microbiol Immunol | volume = 199 | pages = 173–187 | pmid = 7555067] [cite journal | last = Kidd | first = AH | coauthors = Garwicz D, Oberg M | year = 1995 | title = Human and simian adenoviruses: phylogenetic inferences from analysis of VA RNA genes | journal = Virology | volume = 207 | pages = 32–45 | pmid = 95176559 | doi = 10.1006/viro.1995.1049] It plays a role in regulating translation. [cite journal | last = Thimmappaya | first = B | coauthors = Weinberger C, Schneider RJ, Shenk T | year = 1982 | title = Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection | journal = Cell | volume = 31 | pages = 543–551 | pmid = 6297772 | doi = 10.1016/0092-8674(82)90310-5] There are two copies of this RNA called VAI or VA RNAI and VAII or VA RNAII.

Function

VAI stimulates the translation of both early and late viral genes including E3 and hexon. [cite journal | last = Svensson | first = C | coauthors = Akusjarvi G | year = 1984 | title = Adenovirus VA RNAI: a positive regulator of mRNA translation | journal = Mol Cell Biol | volume = 4 | pages = 736–742 | pmid = 6201722] VAII does not stimulate translation. VAI increases the stability of additionally ribosome bound RNAs using a transient transfection assay. [cite journal | last = Strijker | first = R | coauthors = Fritz DT, Levinson AD | year = 1989 | title = Adenovirus VAI-RNA regulates gene expression by controlling stability of ribosome-bound RNAs | journal = EMBO J | volume = 8 | pages = 2669–2675 | pmid = 2583126]

VAI RNA is processed in the cell to create 22 nucleotide long RNAs that can act as siRNA or miRNA. cite journal | author = Sano M, Kato Y, Taira K | title = Sequence-specific interference by small RNAs derived from adenovirus VAI RNA | journal = FEBS Lett. | volume = 580 | issue = 6 | pages = 1553–64 | year = 2006 | pmid = 16472808 | doi = 10.1016/j.febslet.2006.01.085 | issn = ] VAI RNA functions as a decoy RNA for the double stranded RNA activated protein kinase R which would otherwise phosphorylate eukaryotic initiation factor 2.

tructure

VA RNA is composed of two stem-loops separated by a central region essential for function. [cite journal | last = Ma | first = Y | coauthors = Mathews MB | year = 1996 | title = Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I | journal = RNA | volume = 2 | pages = 937–951 | pmid = 8809020]

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • RNA interference — (RNAi) is a mechanism that inhibits gene expression at the stage of translation or by hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (significant for some forms of innate immune response), and …   Wikipedia

  • RNA polymerase II — (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. [cite journal | author = Kronberg, R.D. | title = Eukaryotic… …   Wikipedia

  • RNA-Editing — (deutsch: RNA Editierung) ist ein biochemischer Vorgang innerhalb bestimmter Zellen oder Zellorganellen, der im Verlauf der Genexpression nach der Transkription und vor der Translation stattfinden kann. Der Begriff beschreibt die Modifizierung… …   Deutsch Wikipedia

  • RNA-Edition — RNA Editing (deutsch: RNA Edition) ist ein biochemischer Vorgang innerhalb bestimmter Zellen oder Zellorganellen, der im Verlauf der Genexpression nach der Transkription und vor der Translation stattfinden kann. Der Begriff beschreibt die… …   Deutsch Wikipedia

  • RNA-dependent RNA polymerase — (RDRP), or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template. This is in contrast to a typical RNA polymerase, which catalyzes the transcription of RNA from a DNA template.Viral RDRPs were discovered in the… …   Wikipedia

  • RNA-Polymerase — Enzymklassifikationen EC, Kategorie …   Deutsch Wikipedia

  • RNA-induced silencing complex — RNA induced silencing complex, or RISC, is a multi protein siRNA complex which cleaves (incoming viral) dsRNA and binds short antisense RNA strands which are then able to bind complementary strands. When it finds the complementary strand, it… …   Wikipedia

  • RNA-induced transcriptional silencing — (RITS) is a form of RNA interference by which short RNA molecules such as small interfering RNA (siRNA) trigger the downregulation of transcription of a particular gene or genomic region. This is usually accomplished by posttranslational… …   Wikipedia

  • RNA extraction — is the purification of RNA from biological samples. This procedure is complicated by the ubiquitous presence of ribonuclease enzymes in cells and tissues, which can rapidly degrade RNA. [cite journal |author=Peirson SN, Butler JN |title=RNA… …   Wikipedia

  • RNA-OUT — is a non coding RNA that is antisense to the RNA IN non coding RNA. Transposition of insertion sequence IS10 is regulated by an anti sense RNA which inhibits transposase expression when IS10 is present in multiple copies per cell. RNA OUT… …   Wikipedia

  • RNA polymerase III — (also called Pol III) transcribes DNA to synthesize ribosomal 5S rRNA, tRNA and other small RNAs. The genes transcribed by RNA Pol III fall in the category of housekeeping genes whose expression is required in all cell types and most… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”